Back Story For Mother
“Lots of high % potential health stuff. In real time, mother’s very hormone sensitive . Gets like a Premenstrual dysphoric disorder (PMDD) state , feels depressed. Struggles with anxiety and depression in general . Notice she’s been getting allergies. During the birth of 2nd child two years ago; mother had to get vancomycin because she was strep B positive. When the family get sick, the mother gets the sickest of the 4 of us unfortunately. Mother caught COVID in Sep 2022. Mother’s cycles in 2021 started to be heavy where before that never happened. As a kid, mother was on Accutane a lot. When mothers results through biomesight I also got a message that said unusually small file size or something along those lines.”
Foreword – and Reminder
I am not a licensed medical professional and there are strict laws where I live about “appearing to practice medicine”. I am safe when it is “academic models” and I keep to the language of science, especially statistics. I am not safe when the explanations have possible overtones of advising a patient instead of presenting data to be evaluated by a medical professional before implementing.
I cannot tell people what they should take or not take. I can inform people items that appears to have better odds of improving their microbiome as a results on numeric calculations. I am a trained experienced statistician with appropriate degrees and professional memberships. All suggestions should be reviewed by your medical professional before starting.
- Jason Hawrelak Recommendations – 99.7%ile (better than most), High Roseburia, Blautia. The others are low
Checking on the two studies that I could find Premenstrual dysphoric disorder
- Characteristics of the Gut Microbiota in Japanese Patients with Premenstrual Syndrome 
- Characteristics of the gut microbiota in women with premenstrual symptoms: A cross-sectional study 
If you can locate any other studies, please send to me.
|Bacteroidia (NCBI:200643 )||Low||4%ile|
|Anaerotaenia (NCBI:1843206 )||High||not reported by lab|
|Bifidobacterium (NCBI:1678 )||High||80%ile|
|Blautia (NCBI:572511 )||High||98%ile|
|Butyricicoccus (NCBI:580596 )||Low||not reported by lab|
|Collinsella (NCBI:102106 )||High||0%ile|
|Extibacter (NCBI:1918452 )||Low||not reported by lab|
|Megasphaera (NCBI:906 )||Low||92%ile|
|Parabacteroides (NCBI:375288 )||Low||67%ile|
|Bacteroidetes (NCBI:976 )||Low||4%ile|
This suggests that we have a general match with the literature and should include in our consensus, a hand picked set of suggestions.
We have an impressive list of bacteria deemed unhealthy. Note that counts are often small (agreeing with the abundance of bacteria at low levels seen above).
|Anaerotruncus colihominis||species||78||2380||Not Healthy Predictor||Citation|
|Blautia producta||species||75||1440||Not Healthy Predictor||Citation|
|Collinsella||genus||0||10||High COVID Risk||Citation|
|Dorea||genus||97||23040||Increased COVID risk||Citation|
|Eggerthella lenta||species||99||3469||Not Healthy Predictor||Citation|
|Finegoldia magna||species||91||830||Infectious bacteria||Citation|
|Granulicatella adiacens||species||84||80||Not Healthy Predictor||Citation|
|Peptoniphilus harei||species||67||50||Infectious bacteria||Citation|
|Peptoniphilus lacrimalis||species||78||170||Infectious bacteria||Citation|
|Peptostreptococcus stomatis||species||88||150||Not Healthy Predictor||Citation|
|Prevotella timonensis||species||95||1890||Infectious bacteria||Citation|
|Ruminococcus gnavus||species||99||62200||Not Healthy Predictor||Citation|
|Streptococcus vestibularis||species||65||370||Not Healthy Predictor||Citation|
|Veillonella atypica||species||94||859||Not Healthy Predictor||Citation|
Potential Medical Conditions Detected had at 99%ile, Schizophrenia, which suggests some overlap with PMDD.
I added a new choice to the site that gets canned suggestions for Bacteria Deemed Unhealthy above because of the large number of bacteria flagged in this sample.
The suggestions for this person with this new option.
Building the Consensus
I am building from:
- Hand Picked (see above focused on PMDD) (4 picked)
- Unhealthy Suppression – just added (33 picked)
- Outside Range from Nirvana/CosmosId (5 picked)
- Outside Lab Range (+/- 1.96SD) (6 picked)
- Outside Box-Plot-Whiskers (60 picked)
- Outside Kaltoft-Moldrup (95 picked)
The top items to suggested to take are shown below (meat and B-vitamins are concentric):
- carboxymethyl cellulose (prebiotic)
- low carbohydrate diet
- melatonin supplement
- glycyrrhizic acid (licorice)
- thiamine hydrochloride (vitamin B1)
- gluten-free diet
- vegetable/fruit juice-based diets
- vitamin b3 (niacin)
- high animal protein diet
- high red meat
- Arbutin (polyphenol)
- pyridoxine hydrochloride (vitamin B6)
The top items to suggested to avoid are shown below
- lactobacillus rhamnosus gg (probiotics)
- inulin (prebiotic)
- Burdock Root
- arabinoxylan oligosaccharides (prebiotic)
- saccharomyces boulardii (probiotics)
- brown rice
- lactobacillus reuteri (probiotics)
- fruit/legume fibre
- raw potato starch
- lactobacillus salivarius (probiotics)
- dietary fiber
- sodium butyrate
We have a challenge here, take lactobacillus rhamnosus gg (probiotics) by itself is a -409, but in combination with propionibacterium freudenreichii it is 190-263. This suggests that bacteria as a supplement ( Nutricology/Securil ) or lots of real Emmental cheese (which uses it).
Similarly lactobacillus salivarius (probiotics) is a negative -275 but Lactobacillus salivarius UCC118 is a positive 285. I would avoid it, instead of playing probiotic roulette.
The next one on the list as a reasonable candidate is lactobacillus fermentum (probiotics), then mutaflor escherichia coli nissle 1917 (probiotics).
Going over to KEGG suggestions, the top choices (not in Prescript Assist which is a negative) are (in order)
Which points to microbiome labs/ megasporebiotic OR organic 3 / primal soil (see probiotic page for other choices)
My suggestion for rotation would be:
- Symbioflor-2 (since Mutaflor is not available for this person in the USA)
- A probiotic containing Bacillus subtilis etc