This is reported often in samples, and thus being examined if it reaches our threshold for inclusion as defined in A new specialized selection of suggestions links.
Study Populations:
| Symptom | Reference | Study |
| Histamine or Mast Cell Issues | 1092 | 56 |
- Bacteria Detected with z-score > 2.6: found 143 items, highest value was 8.5
- Enzymes Detected with z-score > 2.6: found 215 items, highest value was 6.1
- Compound Detected with z-score > 2.6: found ZERO items
Interesting Significant Bacteria
One of the top items happens to have probiotics that are known to take up residency – are Symbioflor-2 and Mutaflor. . All of these top items are too low levels
| Bacteria | Reference Mean | Study | Z-Score |
| Prevotella paludivivens (species) | 140 | 21 | 8.5 |
| Prevotella stercorea (species) | 6451 | 45 | 6.1 |
| Escherichia albertii (species) | 912 | 232 | 5.1 |
| Serratia (genus) | 1011 | 275 | 4.9 |
| Serratia entomophila (species) | 987 | 263 | 4.8 |
| Alishewanella (genus) | 35 | 19 | 4.7 |
| Clostridium cellulovorans (species) | 40 | 17 | 4.6 |
| Yersiniaceae (family) | 1032 | 317 | 4.6 |
| Prevotellaceae (family) | 81953 | 28733 | 4.5 |
| Prevotella copri (species) | 65645 | 13994 | 4.5 |
| Escherichia (genus) | 5617 | 1664 | 4.5 |
| Prevotella (genus) | 73889 | 22771 | 4.5 |
| Staphylococcus pseudolugdunensis (species) | 45 | 20 | 4.3 |
| Escherichia coli (species) | 712 | 234 | 4.3 |
| Schaalia naturae (species) | 211 | 37 | 4.3 |
| Atopobiaceae (family) | 132 | 39 | 4.2 |
| Rhodovibrionaceae (family) | 119 | 61 | 4.1 |
| Bulleidia (genus) | 188 | 30 | 4.1 |
Interesting Enzymes
As above, too low levels were most significant
| Enzyme | Reference Mean | Study Mean | Z-Score |
| propanoyl-CoA:oxaloacetate C-propanoyltransferase (thioester-hydrolysing, 1-carboxyethyl-forming) (2.3.3.5) | 1443 | 380 | 6.1 |
| (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase (succinate-forming) (4.1.3.30) | 1395 | 383 | 5.8 |
| S-methyl-5′-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase (2.4.2.28) | 3654 | 1517 | 5.4 |
| UDP-N-acetyl-alpha-D-glucosamine:lipopolysaccharide N-acetyl-D-glucosaminyltransferase (2.4.1.56) | 1008 | 264 | 5.2 |
| (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming] (4.2.1.79) | 1246 | 401 | 5.2 |
| n/a (3.4.23.49) | 1244 | 356 | 5.1 |
| L-carnitinyl-CoA hydro-lyase [(E)-4-(trimethylammonio)but-2-enoyl-CoA-forming] (4.2.1.149) | 1380 | 367 | 5 |
| acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (6,7 cis-dehydrogenating) (1.14.19.3) | 1013 | 302 | 5 |
Interesting Compounds
Nothing was found!!!! In one sense this was a surprise, in another sense, it hints that the results found significant are not random.
Bottom Line
Histamine or Mast Cell Issues appears to a condition of deficiency. Common internet thinking is that it is a condition of a surplus of histamine producing bacteria. It is more likely that the normal histamine consumers are being starved of enzymes that are needed to stop the accumulation of histamine.
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