This is reported often in samples, and thus being examined if it reaches our threshold for inclusion as defined in A new specialized selection of suggestions links.

Study Populations:

Symptom	Reference	Study
Histamine or Mast Cell Issues	1092	56

• Bacteria Detected with z-score > 2.6: found 143 items, highest value was 8.5
• Enzymes Detected with z-score > 2.6: found 215 items, highest value was 6.1
• Compound Detected with z-score > 2.6: found ZERO items

Interesting Significant Bacteria

One of the top items happens to have probiotics that are known to take up residency – are Symbioflor-2 and Mutaflor. . All of these top items are too low levels

Bacteria	Reference Mean	Study	Z-Score
Prevotella paludivivens (species)	140	21	8.5
Prevotella stercorea (species)	6451	45	6.1
Escherichia albertii (species)	912	232	5.1
Serratia (genus)	1011	275	4.9
Serratia entomophila (species)	987	263	4.8
Alishewanella (genus)	35	19	4.7
Clostridium cellulovorans (species)	40	17	4.6
Yersiniaceae (family)	1032	317	4.6
Prevotellaceae (family)	81953	28733	4.5
Prevotella copri (species)	65645	13994	4.5
Escherichia (genus)	5617	1664	4.5
Prevotella (genus)	73889	22771	4.5
Staphylococcus pseudolugdunensis (species)	45	20	4.3
Escherichia coli (species)	712	234	4.3
Schaalia naturae (species)	211	37	4.3
Atopobiaceae (family)	132	39	4.2
Rhodovibrionaceae (family)	119	61	4.1
Bulleidia (genus)	188	30	4.1

Interesting Enzymes

As above, too low levels were most significant

Enzyme	Reference Mean	Study Mean	Z-Score
propanoyl-CoA:oxaloacetate C-propanoyltransferase (thioester-hydrolysing, 1-carboxyethyl-forming) (2.3.3.5)	1443	380	6.1
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase (succinate-forming) (4.1.3.30)	1395	383	5.8
S-methyl-5′-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase (2.4.2.28)	3654	1517	5.4
UDP-N-acetyl-alpha-D-glucosamine:lipopolysaccharide N-acetyl-D-glucosaminyltransferase (2.4.1.56)	1008	264	5.2
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming] (4.2.1.79)	1246	401	5.2
n/a (3.4.23.49)	1244	356	5.1
L-carnitinyl-CoA hydro-lyase [(E)-4-(trimethylammonio)but-2-enoyl-CoA-forming] (4.2.1.149)	1380	367	5
acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (6,7 cis-dehydrogenating) (1.14.19.3)	1013	302	5

Interesting Compounds

Nothing was found!!!! In one sense this was a surprise, in another sense, it hints that the results found significant are not random.

Bottom Line

Histamine or Mast Cell Issues appears to a condition of deficiency. Common internet thinking is that it is a condition of a surplus of histamine producing bacteria. It is more likely that the normal histamine consumers are being starved of enzymes that are needed to stop the accumulation of histamine.