This is a common symptom for both ME/CFS and Long COVID. This is reported often in samples, and thus being examined if it reaches our threshold for inclusion as defined in A new specialized selection of suggestions links. It does.
My default view is that this symptom is likely due to vesicular constriction/inflammation or “stick blood” (which contains many coagulation possibilities) resulting in low warming blood flow.
Study Populations:
Symptom | Reference | Study |
Sleep: Unrefreshed Sleep | 1087 | 78 |
- Bacteria Detected with z-score > 2.6: found 145 items, highest value was 12.6
- Enzymes Detected with z-score > 2.6: found 170 items, highest value was 5.3
- Compound Detected with z-score > 2.6: found No items
The highest z-scores above are more than most other symptoms. This indicates that the causes are more homogeneous bacteria shifts.
![](https://blog.microbiomeprescription.com/wp-content/uploads/2022/07/image-48.png)
Interesting Significant Bacteria
All bacteria found significant had too low levels. The dominant genus is Prevotella with the P.Copri being usually 90% of the genus count in our reference, but only 14% of the genus count with Cold Extremities indicating that the shift is very species specific. Looking at Prevotella copri in isolation, we see the best documented ways of increasing it are: mediterranean diet, resveratrol (grape seed/polyphenols/red wine), berberine, navy bean, Conjugated Linoleic Acid and linseed(flaxseed).
It is interesting to note that some of these are known to improve coagulation or reduces inflammation
- Therapeutic Potential of Resveratrol in COVID-19-Associated Hemostatic Disorders [2021]
- One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease. [2012]
- Interaction between resveratrol and thrombin and its biological implication. [2011]
- Berberine alleviates myocardial ischemia-reperfusion injury by inhibiting inflammatory response and oxidative stress: the key function of miR-26b-5p-mediated PTGS2/MAPK signal transduction. [2022]
- Berberine as a natural modulator of inflammatory signaling pathways in the immune system: Focus on NF-κB, JAK/STAT, and MAPK signaling pathways. [2022]
- Dietary conjugated linoleic acid links reduced intestinal inflammation to amelioration of CNS autoimmunity. [2021]
Bacteria | Reference Mean | Study | Z-Score |
Prevotella copri (species) | 66900 | 3090 | 12.6 |
Prevotella (genus) | 74698 | 21293 | 7.6 |
Prevotellaceae (family) | 82172 | 36608 | 6.1 |
Bifidobacterium kashiwanohense PV20-2 (strain) | 326 | 78 | 5.9 |
Bifidobacterium catenulatum subsp. kashiwanohense (subspecies) | 317 | 78 | 5.8 |
Sporolactobacillaceae (family) | 173 | 58 | 5.7 |
Thermosediminibacterales (order) | 48 | 18 | 5.7 |
Sporolactobacillus (genus) | 174 | 60 | 5.5 |
Sporolactobacillus putidus (species) | 174 | 60 | 5.5 |
Bifidobacterium gallicum (species) | 3784 | 783 | 5.5 |
Lactiplantibacillus pentosus (species) | 123 | 22 | 5.3 |
Phocaeicola coprocola (species) | 7584 | 663 | 5 |
Interesting Enzymes
Most (99%) enzymes found significant had too low levels.
Enzyme | Reference Mean | Study Mean | Z-Score |
n/a (3.4.24.20) | 40 | 16 | 5.3 |
2-acetylphloroglucinol C-acetyltransferase (2.3.1.272) | 182 | 58 | 5.1 |
ATP:L-threonine O3-phosphotransferase (2.7.1.177) | 2416 | 529 | 5 |
Bottom Line
In this study, one species shouts out as the cause by not being there Prevotella copri. I would really emphasis the items listed above as encouraging its growth.
It may be available “soon” as a probiotic, “The gut bacterium Prevotella copri (P. copri) has been shown to lower blood glucose levels in mice as well as in healthy humans, and is a promising candidate for a next generation probiotic aiming at prevention or treatment of obesity and type 2 diabetes.” [2021]
This article is an interesting read: The Strange Case of Prevotella copri: Dr. Jekyll or Mr. Hyde? Especially for those who think all bacteria can be classified as either good or bad.
In terms of retail probiotics suggested, the E.Coli probiotic, Symbioflor-2 is suggested.
![](https://blog.microbiomeprescription.com/wp-content/uploads/2022/07/image-49.png)
The a priori suggestions, shown below, contains the items for P. Copri cited above.
![](https://blog.microbiomeprescription.com/wp-content/uploads/2022/07/image-50.png)
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