It is that season again — and some areas are reporting much higher levels than usual (with predictions for it getting worst). Some people will load themselves up daily on antihistamine, for example, Diphenhydramine HCl , which impacts over 800 different bacteria. We do have a profile of the bacteria shifts seen on Microbiome Prescription.
The bad news is that we have lots of studies, but no good studies — all of them have problems…
” A total of 57 062 articles were derived from searching seven online databases and evidence from 48 RCTs and 10 observational studies were reviewed for methodological quality and risk of bias. No qualitative studies meeting the inclusion criteria could be found, therefore only a quantitative review was performed. ”Health supplements for allergic rhinitis: A mixed-methods systematic review 
- Association of Serum Vitamin D and Immunoglobulin E Levels With Severity of Allergic Rhinitis  ” vitamin D deficiency is associated with increasing severity of allergic rhinitis symptoms.” [2021 ]
- “This MR study found no evidence supporting a causal association between serum 25(OH)D levels and risk of AR, AS and NAR in European-ancestry population. ” 
- Effects of vitamin E and selenium on allergic rhinitis and asthma pathophysiology 
“Our results indicated that vit E could attenuate allergic rhinitis and asthma symptoms; nevertheless, treatment with Se alone was not effective in controlling allergic symptoms. ” 
“Probiotics may be beneficial in improving symptoms and quality of life in patients with allergic rhinitis; however, current evidence remains limited due to study heterogeneity and variable outcome measures. Additional high-quality studies are needed to establish appropriate recommendations.”A systematic review and meta-analysis of probiotics for the treatment of allergic rhinitis 
Probiotic Potential of Lactobacillus Species in Allergic Rhinitis [2021 – full text] is a recent review with two appearing to be most likely effective (to some extent): Lactobacillus Casei and the closely related Lactobacillus Paracasei with dosages up to 30 billion CFU/day. These happen to be less than the suggested dosages from Custom Probiotic.
If we look at Nat.Lib.of Medicine studies at Microbiome Prescription, we do not see any reports of low Lactobacillus. What we do see is low Bifidobacterium) ( Bifidobacterium longum , Bifidobacterium adolescentis, Bifidobacterium catenulatum) and Clostridium butyricum. Logically those seem better candidates!
- Probiotic NVP-1703 Alleviates Allergic Rhinitis by Inducing IL-10 Expression: A Four-week Clinical Trial, a mixture of Bifidobacterium longum and Lactobacillus plantarum… ” Therefore, NVP-1703 can be treatment option for perennial AR.” 
- [Allergic rhinitis management:environment control and patient education]., combined clostridium and bifidobacterium capsules(called Changlekang) – good results
- Probiotics ( Lactobacillus gasseri KS-13, Bifidobacterium bifidum G9-1, and Bifidobacterium longum MM-2) improve rhinoconjunctivitis-specific quality of life in individuals with seasonal allergies: a double-blind, placebo-controlled, randomized trial  “This combination probiotic improved rhinoconjunctivitis-specific quality of life during allergy season for healthy individuals with self-reported seasonal allergies; however, the associated mechanism is still unclear. “
- Bifidobacterium mixture (B longum BB536, B infantis M-63, B breve M-16V) treatment in children with seasonal allergic rhinitis and intermittent asthma  “Children treated with probiotic mixture achieved a significant improvement of symptoms “
Bifidobacterium longum produces a rich collection of end products (1,380), the absence of which may account for hay fever.
I suspect Placebo effect and poor study construction has resulted in the fuzziness for supplements and lactobacillus probiotics. The Nat.Lib.of Medicine profiles points to some specific bacteria that are low and the available studies, appear to suggest that taking those bacteria as probiotics will significantly improve hay fever. The list is:
- Bifidobacterium longum ,
- Bifidobacterium adolescentis,
- Bifidobacterium catenulatum) and
- Clostridium butyricum i.e. Miyarisan
Adequate Vitamins D and E supplementation may also help. I use the word adequate because often the dosages suggested in some studies are insufficient to alter blood level by any reasonable amount in a month (see this post for a formula ) – hence “no effect”.
There is one more path to consider, getting suggestions explicit for the shifts reports.
The results are shown below
We see L.Casei, L. Paracasei and Clostridium butyricum on the recommended list — in agreement with the above. Further down, we see Selenium (cited above) also listed
The above is evidence based on the microbiome shifts seen with hay fever.
2 thoughts on “Hay Fever / Allergic Rhinitis – What we know”
So again there is no clear answer and one size supplement fits all.
To raise bifido would it be much easier to supplement with Holigos ?
Does Holigos carry negative aspects of it ?(“can raise unwanted bad bacteria”)
I know this a naïve question.
There are rarely comparison studies — almost all are X versus control group, not X vs Y.
Every supplement have potential risks — do a web search for the supplement and adverse effects.
See https://microbiomeprescription.com/library/details?taxon=1678 , Holigos has the most studies finding that it increases.
There are many other items listed there (with number of studies reporting).
NOTE Especially the items that DECREASES IT — often the key is to remove those at the same time