Psychoactive Probiotics! – 2024 Update for Dopamine

A reader asked me to do an update of my 2016 post Psychoactive Probiotics! There has been a lot of recent literature as shown on PubMed. Note that often these are strain specific and not generalized for species cited below. If you cannot find the strains specified in the studies, it may be worthwhile trying different brands of the species (with the most studied species being most probable).

Excessive Dopamine may be associated with: Mania or Hypomania, Psychosis, Substance Use Disorders, Hyperactivity and Impulsivity, Tics and Tourette Syndrome, Sleep Disorders, Huntington’s Disease and Excessive Reward Seeking Behavior. Insufficient dopamine may be associated with: Parkinson’s Disease, Depression, Attention-Deficit/Hyperactivity Disorder (ADHD), Drug Addiction and Substance Use Disorders, Restless Legs Syndrome, Schizophrenia and Huntington’s Disease.



The following appears to reduce dopamine

Lacticaseibacillus casei LA205 and Lacticaseibacillus paracasei LA903 REDUCES Dopamine [2023]

Lactobacillus delbrueckii  [2021]

Lactobacillus plantarum DR7 [2019] but increases serotonin 

Bifidobacterium CECT 7765 [2017]