There is growing acceptance that specific conditions have a pattern of microbiome shifts. There is likely a complex two way interaction between conditions and the microbiome. We do know from both studies and personal experience, that symptoms associated with a condition decreases as the microbiome shift closer to normal or typical.
The templates are a summary of abnormal shifts reported on the US National Library of Medicine. There are often technical issues with these studies, a few simple examples.
- Patients are often from the same medical practise, so they have been subject to interventions — the results may reflect the interventions and not the actual conditions. If 50% of the patients are gluten free, the results may reflect being gluten free and not the condition.
- Region effects in diet or even patient traditional lab results can impact the microbiome. A study of patients in Bangor, Maine vs Miami, Florida will likely show significant different levels of Vitamin D. We know that Vitamin D impacts the microbiome (see this listing on the site).
The condition templates is an aggregation of everything reported in the literature. There is no review or evaluation of the study — which is intentional, because there are often very few published studies. For some bacteria you will see ‘High or Low’ which means often that one study reported high levels and a different one reported low. The complexity of microbiome interactions means there is no single right answer.
What has reports to date?
This list has grown a lot over the last year and will likely keep growing.
- Alzheimer’s disease
- Amyotrophic lateral sclerosis (ALS) Motor Neuron
- Ankylosing spondylitis
- Autoimmune Disease
- Barrett esophagus cancer
- Brain Trauma
- Celiac Disease
- Chronic Fatigue Syndrome
- Chronic Kidney Disease
- Colorectal Cancer
- Crohn’s Disease
- Functional constipation / chronic idiopathic constipation
- Gastro-esophageal reflux disease (Gerd)
- Generalized anxiety disorder
- Graves’ disease
- Hashimoto’s thyroiditis
- High Blood Pressure
- Histamine Issues
- Histamine Issues From Ubiome
- IgA nephropathy (IgAN)
- Inflammatory Bowel Disease
- Iron Consumers
- Irritable Bowel Syndrome
- Juvenile idiopathic arthritis
- Liver Cirrhosis
- Metabolic Syndrome
- Mood Disorders
- Multiple Sclerosis
- Non-alcoholic Fatty Liver Disease
- Non-Celiac Gluten Sensitivity
- Parkinson’s Disease
- Rheumatoid arthritis
- rheumatoid arthritis (RA) and Spondyloarthritis (SpA)
- Sjögren syndrome
- Small Intestinal Bacterial Overgrowth (SIBO)
- Stress / post-traumatic stress disorder
- Systemic Lupus Erythematosus
- Type 1 Diabetes
- Type 2 Diabetes
- Ulcerative colitis
A “Match” does not mean the condition
If you have the condition, then this can be helpful for getting a sense of where you are. Having less matches usually implies less symptoms.
The numbers below are for myself:
It says that the flare was likely caused by an overgrowth (HIGH jumped by 42%). It does not pinpoint one bacteria — in reality, the issue is a consortium of different bacteria reinforcing each other.
Shifts in the following 4 genus are seen across 20 of these conditions. It is unlikely that you have all 20 conditions.