Alternative Title: Climate Change and your guts!

This is a common symptom for both ME/CFS and Long COVID. This is reported often in samples uploaded. We examine if the data reaches our threshold for inclusion as defined in A new specialized selection of suggestions links. It does.

My default view is that this symptom is likely due to vesicular constriction/inflammation or “sticky blood” (which contains many possible coagulation issues). This results in slow blood flow causing issues with transferring heat to and from the body.

• temperature intolerance is generally placed under dysautonomia

Study Populations:

Symptom	Reference	Study
Intolerance of extremes of heat and cold	1159	54

• Bacteria Detected with z-score > 2.6: found 247 items, highest value was 8.8
• Enzymes Detected with z-score > 2.6: found 501 items, highest value was 6.7
• Compound Detected with z-score > 2.6: found No items

The number of bacteria and enzymes that are significant hints that it is a complex scenario, possibly with different subsets.

Interesting Significant Bacteria

All bacteria found significant had too low levels. The dominant order is Anaeroplasmatales and three significant genus are Holdemanella, Eubacterium, and Escherichia. Every one of the 247 bacteria found significant was LOW.

Bacteria	Reference Mean	Study	Z-Score
Holdemanella biformis (species)	3370	350	8.8
Holdemanella (genus)	3379	350	8.8
Eubacterium (genus)	2507	586	7.8
Lysobacter deserti (species)	29	11	6.5
Anaerolineae (class)	87	35	5.7
Opitutae (class)	163	46	5.5
Puniceicoccaceae (family)	158	44	5.5
Legionellales (order)	82	41	5.4
Leptospiraceae (family)	67	22	5.4
Leptospira (genus)	67	22	5.4
Leptospirales (order)	67	22	5.4
Leptospira licerasiae (species)	67	22	5.4
Bifidobacterium cuniculi (species)	79	26	5.3
Lactiplantibacillus pentosus (species)	116	22	5.3
Puniceicoccales (order)	110	37	5.3
Legionellaceae (family)	81	41	5.2
Legionella (genus)	81	41	5.2
Anaeroplasmataceae (family)	8102	20	5.2
Anaeroplasma (genus)	8102	20	5.2
Anaeroplasmatales (order)	8102	20	5.2
Chloroflexi (phylum)	128	55	5.1
Cerasicoccus arenae (species)	537	80	5.1
Caldilineaceae (family)	90	35	5.1
Caldilinea (genus)	90	35	5.1
Caldilineales (order)	90	35	5.1
Caldilinea tarbellica (species)	90	35	5.1
Caldilineae (class)	90	35	5.1
Escherichia (genus)	6016	1367	5.1
Cerasicoccus (genus)	312	60	5

Interesting Enzymes

Atypical distribution for enzymes in these studies, the number of highs and lows were of the same magnitude. 268 enzymes were low and 233 enzymes were high (see 2nd table) but none above our listing threshold of 5.0.

Enzyme	Reference Mean	Study Mean	Z-Score
(S)-2-hydroxyglutarate:quinone oxidoreductase (1.1.5.13)	2214	398	6.7
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase (succinate-forming) (4.1.3.30)	1444	360	6.3
propanoyl-CoA:oxaloacetate C-propanoyltransferase (thioester-hydrolysing, 1-carboxyethyl-forming) (2.3.3.5)	1491	387	6.3
propanoate:CoA ligase (AMP-forming) (6.2.1.17)	1894	483	6.1
D-galactaro-1,4-lactone lyase (ring-opening) (5.5.1.27)	1698	393	5.8
thiosulfate:ferricytochrome-c oxidoreductase (1.8.2.2)	1381	272	5.4
gamma-butyrobetainyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase (1.3.8.13)	1400	441	5.4
glutarate, 2-oxoglutarate:oxygen oxidoreductase ((S)-2-hydroxyglutarate-forming) (1.14.11.64)	1299	297	5.4
(E)-4-(trimethylammonio)but-2-enoyl-CoA:L-carnitine CoA-transferase (2.8.3.21)	1386	440	5.4
L-carnitinyl-CoA hydro-lyase [(E)-4-(trimethylammonio)but-2-enoyl-CoA-forming] (4.2.1.149)	1444	321	5.4
2-dehydrotetronate isomerase (5.3.1.35)	1406	482	5.3
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming] (4.2.1.79)	1297	439	5.2
3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating) (1.14.12.19)	581	142	5.2
1-aminocyclopropane-1-carboxylate aminohydrolase (isomerizing) (3.5.99.7)	1431	416	5.2
n/a (3.4.23.49)	1307	326	5.2
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate:NAD+ oxidoreductase (1.3.1.87)	568	140	5.2
ATP:2′-deoxyadenosine 5′-phosphotransferase (2.7.1.76)	1974	344	5.2
carotenoid beta-end group lyase (ring-opening) (5.5.1.19)	1452	201	5.1
RNA-3′-phosphate:RNA ligase (cyclizing, AMP-forming) (6.5.1.4)	1220	316	5.1
NTP:deoxycytidine 5′-phosphotransferase (2.7.1.74)	1885	287	5.1
L-threonate:NAD+ 2-oxidoreductase (1.1.1.411)	1410	492	5.1
succinyl-CoA:3-oxo-acid CoA-transferase (2.8.3.5)	1307	363	5.1
acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (6,7 cis-dehydrogenating) (1.14.19.3)	1063	277	5
L-carnitine:CoA ligase (AMP-forming) (6.2.1.48)	1373	517	5
hydrogen-sulfide:flavocytochrome c oxidoreductase (1.8.2.3)	1165	161	5
L-methionine methanethiol-lyase (deaminating; 2-oxobutanoate-forming) (4.4.1.11)	1272	288	5
L-carnitine,NAD(P)H:oxygen oxidoreductase (trimethylamine-forming) (1.14.13.239)	1186	320	5
4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming) (4.1.3.16)	29	9	5

Bottom Line

Temperature intolerance is not an independently study topic. Existing studies are usually in the context of some other condition. This suggests that this is the first study on it’s microbiome.

•  “Diabetes is often associated with orthostatic hypotension and temperature intolerance.” [2005]

The suggestions below has some surprises on the to avoid list: Vitamins B-3, B-12, Curcumin,  N-Acetyl Cysteine (NAC) sitting high in the list with antibiotics. The absence of probiotics in the to take suggestions is note worthy for those that view probiotics as ‘cure all’. Not listed, but conceptually worth considering, are the E.Coli probiotics (Symbioflor-2 or Mutaflor).

Recently I have see pea appear often and I recall that peas were served with most meals as a child. Peas has largely disappear from the western menu. I am starting to wonder if having pea soup 3 times a week would help a lot of people.