Fungi: Pleosporales / Dothideomycetes

Fungi and the microbiome finally got on my radar. Apologies to some, but there is a lot of different items on the microbiome radar screen.

“Small intestinal fungal overgrowth (SIFO)… Two recent studies showed that 26 % (24/94) and 25.3 % (38/150) of a series of patients with unexplained GI symptoms had SIFO. …. but evidence for eradication is lacking.”Small intestinal fungal overgrowth [2015]

As I did with taxa years ago, I will be writing a blog on each one reviewing the literature. If there is sufficient data at the end, I may add it as a feature to Microbiome Prescription.

One of my reader’s results motivated this choice. The data from a Thorne Microbiome Test. About 8 out of 10 people have less of it. The person also has a Crohn’s diagnosis (with SIBO and IBS earlier).

Preventive for Fungi

The following are suggestions:

  • Reduce and keep your living space humidity at 50% or lower (typically done by dehumidifiers). EPA recommends 30-50% [EPA]; we set our dehumidifiers for 35%.

Moisture parameters and fungal communities associated with gypsum drywall in buildings [2015]

Remember, all fungi are not the same. Antibacterial and Antifungal Activities of Spices [2017] does not mention all fungi that I am reviewing. Additionally, some spices are known to have Fungal Contamination of some Common Spices [2022] and Fungi and aflatoxins associated with spices in the Sultanate of Oman [2002] which included cloves (often deem an antifungal).

Basic Information

Thorne only provided only order-level information unfortunately.

Organisms of the genus Bipolaris [a member of Pleosporales] are found in the soil and plant material. These fungi are known to be plant pathogens and infection may result from either inoculation or inhalation of the organism. Infections due to this genus are probably more common than previously recognized and have been increasingly reported in apparently immunocompetent[healthy] hosts. Currently, they should be included in the differential diagnosis of disseminated fungal disease. Genus Bipolaris have been associated with central nervous system infections, sinusitis, keratitis, peritonitis associated with continuous ambulatory peritoneal dialysis, orbitopathy and allergic bronchopulmonary disease. .
In addition to the ability of this genus to cause invasive as well as ‘allergic’ disease in humans, it is
reported that a rnycotoxin produced by Bipolaris may induce lung and liver adenomas ill mice

Disseminated Bipolaris Infection in an Immunocompetent Host: An Atypical Presentation [2000]

Deep cutaneous fungal infection by Pleosporales: An exceptional pathogen in tropical Taiwan [2020] reports successful treatment with 200 mg of oral itraconazole daily for 2-10 months.

Bottom Line

Our ability to drill down further is limited because the results only report at the order level. Itraconazole, an antifungal that is the top choice for other fungi reviewed appears to work.

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