Multiple COVID leading to Heart Issues?

Back Story

We’ve had COVID over half a dozen times since early 2020. My primary symptoms are fatigue, brain fog, and breathlessness/lack of endurance. But the full list of symptoms is long… It’s gotten so bad that I’m out of work. 

I felt brief but significant improvement with low-dose naltrexone, and with low-dose nicotine patches (wasn’t a fan of using that, but it was a successful experiment). 

We’re on a ton of supplements with the guidance of our doctors, but our symptoms are worse than ever, and getting worse with time. We think our microbiomes have been damaged, which the Biomesight results seem to agree with. 

Looking at what is reported for Long COVID, we have few matches:  (5 %ile) 24 of 212, but wtih   Coronary artery disease (93 %ile) 6 of 18. This hints at a different direction which the literature indicating that it is possible.

Patients with COVID-19 were at increased risk of a broad range of cardiovascular disorders including cerebrovascular disorders, dysrhythmias, ischemic and non–ischemic heart disease, pericarditis, myocarditis, heart failure, and thromboembolic disease.

The COVID Heart—One Year After SARS-CoV-2 Infection, Patients Have an Array of Increased Cardiovascular Risks [2022]

As well as Long-term cardiovascular outcomes of COVID-19 [2022].


  • Potential Medical Conditions Detected has nothing of concern
  • Prevotella copri is at 88%ile indicating a significant risk of mycotoxin (from fungi) being present. We also have:
    • ”As with ongoing symptomatic COVID-19, multiple Prevotella species (38) are associated with long COVID. Prevotella species are overrepresented in patients with COVID-19 and are thought to produce proteins that can promote SARS-CoV-2 infection and increase clinical severity of COVID-19 (42).” which may account for the multiple COVID.
  • Dr. Jason Hawrelak Recommendations is at 99.9%ile with low Akkermansia and Bifidobacterium being main item of concern.

We have the typical over representation of bacteria in the 0-9%ile.

0 – 95373
10 – 191618
20 – 291122
30 – 391521
40 – 491523
50 – 591116
60 – 691522
70 – 792417
80 – 891317
90 – 9975

With the following being flagged of concern:

  • Roseburia – 99%ile and 17% of the microbiome
  • Ruminococcus bromii – 96%ile and 5.9% of the microbiome

Roseburia is reported to be decreased in several COVID studies [2021] [2022] [2023] hence the shifts are unlikely to be strongly COVID associated. Similarly a decrease of Ruminococcus is seen after COVID vaccination [2022]. Increases in Ruminococcus is reported in chronic heart failure patients [2018] and atrial fibrillation[2019]

Going Forward

Doing the “Just give Me Suggestions” and then looking at the consensus, we see diet changes at the top of the list:

In other words, lean meat diet.

The top probiotics are:

Going over to KEGG Derived: We see Escherichia coli on the top, with Lacticaseibacillus rhamnosus, Bifidobacterium bifidum, and lactobacillus salivarius being on the positive list (agreement on suggestions with two different algorithms)

I am inclined to suggest diet changes with rotating probiotics every 2 weeks (making sure that you have therapeutic dosages). Retest after 8 weeks and see where we moved to.

Bottom Line

The assumption of typical long COVID or ME/CFS were reasonable assumptions with no microbiome data. You may wish to review other reviews of Long COVID patients. see Analysis Posts on Long COVID and ME/CFS. However, when we add in microbiome data we do not find a match — instead we have indicators of possible cardiac issues arising out of COVID. I would suggest asking for an in depth analysis by your medical professional in this direction.

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