Possible help for the root of all evil in the microbiome?

Using my last post, The root of all evil in the Microbiome?, I tried identifying items that address many of the evils. The process is simple, I use Microbiome Prescription existing database with 2,099.126 interactions between gut modifiers and bacteria. I then select items that only increase the top N items. Starting with 2 items and then working up.

Two Items: Prevotella, Veillonella

Produced following items

  • Amino Acid and similar
    • acetic acid
    • l-citrulline
      • propionate
  • Antibiotics, Antivirals etc
    • rifaximin (antibiotic)s
  • Diet Style
    • ketogenic diet
  • Food (excluding seasonings)
    • blackcurrant
    • cranberry bean flour
    • Far infrared Sauna
    • fasting
    • lupin seeds (anaphylaxis risk, toxic if not prepared properly)
    • Miso
    • pea (fiber, protein)
    • Pulses
    • red wine
    • wheat bran
  • Herb or Spice
    • Bofutsushosan
    • chinensis (Chinese goldthread)
    • isobutyric acid
    • isovaleric acid(fatty acid)
    • smoking
  • Prebiotics and similar
    • arabinoxylan oligosaccharides (prebiotic)
    • galacto-oligosaccharides (prebiotic)
    • xylan (prebiotic)
  • Probiotics
    • Lentilactobacillus buchneri
  • Sugar and similar
    • non-starch polysaccharides
    • saccharin
  • Vitamins, Minerals and similar
    • vitamin d

Three Items: Prevotella, Veillonella, Clostridium

We are done to just one item: Amino Acid and similar l-citrulline

This is not unexpected, in building the suggestions algorithms, I often encountering items that helps one and hurts another; also a lack of studies.

Alternative Approach

I am going to pick the top dozen (12) genus, and then select the items by the number of genus positively impacted. As you see, the best that we get is impacting 50% of the genus picked.

Remember: we are doing items with absolutely positive impact only. We exclude all items that has a negative impact on any of the genus reported in any study. For clarity, if a substance increases a genus in some studies and decreases in other studies, it is excluded. This is the most conservative approach.

Caution: this assumes undergrowth for all 12 genus. It may make an overgrowth worse.

Prescription – Otherproton-pump inhibitors (prescription)6
Sugar and similarnon-starch polysaccharides5
Amino Acid and similaracetic acid3
Amino Acid and similarConjugated Linoleic Acid3
Amino Acid and similarl-citrulline3
Amino Acid and similarproline (amino acid)3
Diet Styleanimal-based diet3
Food (excluding seasonings)blackcurrant3
Food (excluding seasonings)fasting3
Food (excluding seasonings)lupin seeds (anaphylaxis risk, toxic if not prepared properly)3
Food (excluding seasonings)Pulses3
Food (excluding seasonings)safflower oil3
Food (excluding seasonings)wheat bran3
Miscellaneous, food additives, and other odd itemsisobutyric acid3
Miscellaneous, food additives, and other odd itemsisovaleric acid(fatty acid)3
Prebiotics and similararabinoxylan oligosaccharides (prebiotic)3
Sugar and similarsaccharin3
Amino Acid and similarpropionate2
Diet Stylefibre-rich macrobiotic ma-pi 2 diet2
Food (excluding seasonings)barley,oat2
Food (excluding seasonings)cranberry bean flour2
Food (excluding seasonings)Miso2
Food (excluding seasonings)navy bean2
Food (excluding seasonings)pectin2
Food (excluding seasonings)red alga Laurencia tristicha2
Herb or SpiceBofutsushosan2
Herb or Spicecoptis chinensis (Chinese goldthread)2
Herb or Spiceplantago asiatica l.2
Herb or Spiceschisandra chinensis(magnolia berry or five-flavor-fruit)2
Miscellaneous, food additives, and other odd itemsTributyrin2
Prebiotics and similarcarboxymethyl cellulose (prebiotic)2
Prebiotics and similaroligofructose (prebiotic)2
Prebiotics and similarresistant maltodextrin2
Prescription – Otherepicor2
Probioticsbacillus subtilis natto (probiotics)2
Probioticssaccharomyces boulardii (probiotics)2
Sugar and similarglucose (sugar)2
Sugar and similarlevan2
Vitamins, Minerals and similarFerric citrate2

Bottom Line

The above is a generic list that should “do no harm” for most people and will likely help. Better results are likely to occur using a 16s microbiome report (OmbreLabs [US only] and Biomesight [World wide] are the most used) and using the Artificial Intelligence on Microbiome Prescription that factors in the 2 million facts that it has available (see this example). That would produce a targeted list for your needs.