Special Study: Histamine or Mast Cell Issues

This is reported often in samples, and thus being examined if it reaches our threshold for inclusion as defined in A new specialized selection of suggestions links.

Suggestions are available on Changing Microbiome tab on https://microbiomeprescription.com/

Study Populations:

SymptomReferenceStudy
Histamine or Mast Cell Issues109256
  • Bacteria Detected with z-score > 2.6: found 143 items, highest value was 8.5
  • Enzymes Detected with z-score > 2.6: found 215 items, highest value was 6.1
  • Compound Detected with z-score > 2.6: found ZERO items

Interesting Significant Bacteria

One of the top items happens to have probiotics that are known to take up residency – are Symbioflor-2 and Mutaflor. . All of these top items are too low levels

BacteriaReference MeanStudyZ-Score
Prevotella paludivivens (species)140218.5
Prevotella stercorea (species)6451456.1
Escherichia albertii (species)9122325.1
Serratia (genus)10112754.9
Serratia entomophila (species)9872634.8
Alishewanella (genus)35194.7
Clostridium cellulovorans (species)40174.6
Yersiniaceae (family)10323174.6
Prevotellaceae (family)81953287334.5
Prevotella copri (species)65645139944.5
Escherichia (genus)561716644.5
Prevotella (genus)73889227714.5
Staphylococcus pseudolugdunensis (species)45204.3
Escherichia coli (species)7122344.3
Schaalia naturae (species)211374.3
Atopobiaceae (family)132394.2
Rhodovibrionaceae (family)119614.1
Bulleidia (genus)188304.1

Interesting Enzymes

As above, too low levels were most significant

EnzymeReference MeanStudy
Mean
Z-Score
propanoyl-CoA:oxaloacetate C-propanoyltransferase (thioester-hydrolysing, 1-carboxyethyl-forming) (2.3.3.5)14433806.1
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase (succinate-forming) (4.1.3.30)13953835.8
S-methyl-5′-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase (2.4.2.28)365415175.4
UDP-N-acetyl-alpha-D-glucosamine:lipopolysaccharide N-acetyl-D-glucosaminyltransferase (2.4.1.56)10082645.2
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming] (4.2.1.79)12464015.2
n/a (3.4.23.49)12443565.1
L-carnitinyl-CoA hydro-lyase [(E)-4-(trimethylammonio)but-2-enoyl-CoA-forming] (4.2.1.149)13803675
acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (6,7 cis-dehydrogenating) (1.14.19.3)10133025

Interesting Compounds

Nothing was found!!!! In one sense this was a surprise, in another sense, it hints that the results found significant are not random.

Bottom Line

Histamine or Mast Cell Issues appears to a condition of deficiency. Common internet thinking is that it is a condition of a surplus of histamine producing bacteria. It is more likely that the normal histamine consumers are being starved of enzymes that are needed to stop the accumulation of histamine.

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