Special Studies: Tinnitus (ringing in ear)

Tinnitus is not usually viewed as a microbiome issue. It was worth checking if it reaches our threshold for inclusion as defined in A new specialized selection of suggestions links. It did, hence this post

Study Populations:

SymptomReferenceStudy
Neurological-Audio:Tinnitus (ringing in ear)107573
  • Bacteria Detected with z-score > 2.6: found 129 items, highest value was 6.3
  • Enzymes Detected with z-score > 2.6: found 493 items, highest value was 7.1
  • Compound Detected with z-score > 2.6: found ZERO items

This is similar to Special Study: Histamine or Mast Cell Issues in finding no compounds, but the bacteria factor appears weaker and the enzymes is more.

Interesting Significant Bacteria

We have two dominant items that may be addressed by probiotics: Low Bifidobacterium and Low E.Coli

  • E.Coli probiotics are Symbioflor-2 and Mutaflor.
  • Bifidobacterium probiotics: we have 4 in the top group. Unfortunately none of these species are available at the retail level (that I am aware of). Checking interactions for these 4, there was no significant interactions found with common retail bifidobacterium species, just with the general genus.

Looking at Lactobacillus taiwanensis, there is a solid positive association with Bifidobacterium cuniculi and a weaker association with Bifidobacterium catenulatum subsp. kashiwanohense. There is also a weak association with two retail probiotic species: Bifidobacterium bifidum and Bifidobacterium animalis. It was interesting to note that there was no associations with any retail Lactobacillus species.

Bottom line appears to become: E.Coli probiotics, Bifidobacterium bifidum and Bifidobacterium animalis

All of the significant bacteria has too low levels.

BacteriaReference MeanStudyZ-Score
Bifidobacterium gallicum (species)37545346.3
Prevotella stercorea (species)66141026
Bifidobacterium subtile (species)82325.3
Escherichia coli (species)7161705.3
Lactobacillus taiwanensis (species)85125.3
Catenibacterium mitsuokai (species)432345.2
Bifidobacterium cuniculi (species)81285.1
Enterobacteriaceae (family)894826225
Bifidobacterium catenulatum subsp. kashiwanohense (subspecies)313715

Interesting Enzymes

As above, all levels that were found significant had too little. I will leave it to the reader to go to Kyoto Encyclopedia of Genes and Genomes to learn about these enzymes (a steep learning curve).

EnzymeReference MeanStudy
Mean
Z-Score
[cysteine desulfurase]-S-sulfanyl-L-cysteine:[molybdopterin-synthase sulfur-carrier protein]-Gly-Gly sulfurtransferase (2.8.1.11)532620437.1
gamma-L-glutamyl-L-cysteinyl-glycine:spermidine amidase (3.5.1.78)321210666.3
gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) [spermidine is numbered so that atom N-1 is in the amino group of the aminopropyl part of the molecule] (6.3.1.8)321210666.3
tRNA-uridine13 uracil mutase (5.4.99.27)367112466.3
donor:hydrogen-peroxide oxidoreductase (1.11.1.21)30528696.2
S-adenosyl-L-methionine:tRNA 5-(aminomethyl)-2-thiouridylate N-methyltransferase (2.1.1.61)368613056.1
5-oxo-L-proline amidohydrolase (ATP-hydrolysing) (3.5.2.9)1018035056.1
thioredoxin:protein disulfide oxidoreductase (dithiol-forming) (1.8.4.16)381213016.1
acetyl-CoA:N6-hydroxy-L-lysine 6-acetyltransferase (2.3.1.102)7191436.1
UDP-alpha-D-glucose:enterobactin 5′-C-beta-D-glucosyltransferase (configuration-inverting) (2.4.1.369)8191416.1
S-adenosyl-L-methionine:tRNA (uracil54-C5)-methyltransferase (2.1.1.35)381712736.1
L-methionine:2-oxo-acid aminotransferase (2.6.1.88)27718156.1

Interesting Compounds

Nothing was found again!!!! In one sense this was a surprise, in another sense, it hints that the results found significant are not random.

Bottom Line

This was an interesting analysis because the dominant deficiencies were in genus that are available as probiotics. In reality, it points to just 3 probiotics: an E.Coli probiotic and two bifidobacterium. Food suggestions will be generated on Microbiome Prescription using an individual’s unique microbiome.

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From The Gut Club: Stool Test Discussion Group

I went and looked at these two in combinations and got a lot of bacteria in common

Bacteria NameTaxonomy rank
Nostocgenus
Citrobactergenus
Anaerococcus lactolyticusspecies
Streptomycetalesorder
Negativicoccus succinicivoransspecies
Sutterella stercoricanisspecies
Streptomycetaceaefamily
Negativicoccusgenus
Lactococcus fujiensisspecies
Actinomycetaceaefamily
Prevotella disiensspecies
Prosthecobactergenus
Clostridium chartatabidumspecies
Olivibactergenus
Peptoniphilus asaccharolyticusspecies
Butyricimonas synergisticaspecies
Campylobacteralesorder
Epsilonproteobacteriaclass
Campylobacteraceaefamily
Pedobacter kwangyangensisspecies
Staphylococcus pseudolugdunensisspecies
Enterobacteralesorder
Streptococcus millerispecies
Schaaliagenus
Enterobacteriaceaefamily
Mitsuokellagenus
Gammaproteobacteriaclass
Prevotellaceaefamily
Clostridium cellulovoransspecies
Schaalia naturaespecies
Enterobacteriaceae incertae sedisnorank
Blochmanniagenus
Bulleidiagenus
Bifidobacterium cuniculispecies
Prevotellagenus
Escherichiagenus
Prevotella coprispecies
Bifidobacterium gallicumspecies
Escherichia colispecies
Prevotella stercoreaspecies
Prevotella paludivivensspecies

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