At present in our citizen science database we have samples reporting brain fog for:

• Biomesight: 124 samples
• Ombre/Thryve: 151 samples
• UBiome/Thryve: 170 samples

Results from different labs cannot be safely aggregated, so we will investigate on a lab by lab basis. One lab will read data as bacteria A and a different lab as bacteria B.

For very different and strong results using the same process see: Long COVID: microbiome scents – we smell a skunk!

Taxon Patterns

By bacteria found nothing common across labs.

Bacteria	ubiome	Ombre	BiomeSight
Faecalibacterium	Low
Subdoligranulum	Low
Hespellia		High
Porphyromonas		High
Oscillibacter		High
Anaerovibrio			High
Streptococcus			High

End Product Patterns

Ubiome was nothing significant. As above, nothing was in common between the labs. End Products have been weak to predict in prior analysis.

End Product	uBiome	Ombre	Biome Sight
Bacteriocin: (several)		Less
Daidzein		Less
L-Tryptophan		Less
Gamma-Amino butyric acid (GABA)		Less
Urolithins		Less
Pyruvic acid			Less
Methanol			Less
Pentanol			Less

KEGG Enzyme Patterns

ubiome gave 280 candidates, biomesight just 2, ombre had 40 candidates. There was nothing in common.

Enzyme	uBiome	Ombre	BiomeSight
(1->4)-alpha-D-galacturonan lyase	High
15-cis-phytoene:acceptor oxidoreductase (lycopene-forming)	High
nitrous oxide:ferricytochrome-c oxidoreductase	High
CDP-choline phosphohydrolase		High

KEGG Product

Biomesight returned nothing, Ombre just 7 candidates and ubiome 23. There was nothing in common.

KEGG Substrate

Biomesight returned 2 candidates, Ombre returned 42 candidates and ubiome 86. There were a few things in common between Ombre and uBiome. False Detection rate is a risk.

• (S)-Ureidoglycolate – much higher consumption
• 2-O-(alpha-D-Glucopyranosyl)-D-glycerate – much higher consumption
• Formyl-CoA – much higher consumption
  • Mentioned with coagulation in Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism
• S-Formylglutathione – much higher consumption

Bottom Line

I am disappointed in not finding many associations. I will pass the torch to others to see if there is literature connecting these to coagulation or vascular constriction/dilatation .