A reader pointed me at S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis [2021]. There is a prescription drug, PAR-1 INHIBITORS, that appears to help (with some risks).

It is not all strains of Staphylococcus aureus, but about 10% of the strains.

Normally, I look at modifying the gut microbiome — but many items are likely to help. So the question becomes, what are possible for use as skin ointments?

From the list of inhibitors, likely candidates are:

• Zinc or silver ointments
• acetic acid (vinegar) – likely diluted, possibly with a sprayer
• The following available as oils, mixed with creams:
  • oregano oil (2nd high studies)
  • thyme oil (MOST STUDIES)
  • lauric oil / coconut oil
  • clove oil
  • cinnamon oil
  • peppermint oil
  • coriander oil
    
• Other items that may be semi liquid:
  • Vitamin D
  • glycerol monolaurate (Monolaurin)
  • Chlorine Dioxide Solution (CDS)
• Following in solution
  • aspartame (sweetener)
  • saccharin
  • stevia
  • sucralose

The following should NOT be applied to the skin:

• Olive oil

User Feedback

A person with this issue looked over the list and found that the items in the above list that she has tried, reduced the itch.

The obvious cheapest solution to try is simple: a shower with soap (ideally antibacterial soap). Followed by using a spray bottle with vinegar that is allowed to dry on the skin.

• The effect of antibacterial soap with 1.5% triclocarban on Staphylococcus aureus in patients with atopic dermatitis [2000] – reduces, not eliminated
• Bactericidal effects of triclosan in soap both in vitro and in vivo [2015] – the soap needs to be kept on the skin for a while to be effective. i.e. not just wash with soap and immediately rinse.
• Effects of an Antibacterial Soap on the Ecology of Aerobic Bacterial Flora of Human Skin [1975]
• Microbicidal effects of plain soap vs triclocarban-based antibacterial soap [2016]

Other items that inhibits: [2012]

• paroxetine
• hydroxyzine
• atomoxetine
• bencyclane fumarate