Table of Probiotic Impact on Irritable Bowel Syndrome

This has just been published: Efficacy of probiotics, prebiotics and synbiotics in irritable bowel syndrome: a systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials [Sep 2023]

I have done a strikethru on items that are likely waste of money (based on P Value). 0.001 is better than .04.

Number of trialsNumber of patientsRR of persistence of global symptoms (95% CI)P value for the differenceI2 (P value for χ2)
All patients
 All combination probiotics3233690.78 (0.71–0.87)<.00171% (<.001)
VSL#341550.78 (0.53–1.16).2347% (.13)
Lactobacillus paracasei ssp paracasei F19, Lactobacillus acidophilus La5, and Bifidobacterium lactis Bb1232690.92 (0.76–1.11).3814% (.31)
Enterococcus faecalis DSM16440 and Escherichia coli DSM1725226860.71 (0.33–1.51).3797% (<.001)
LacClean Gold S21300.59 (0.37–0.93).020% (.56)
Duolac 7s2760.62 (0.43–0.89).0090% (.62)
 All Lactobacillus strains1614980.84 (0.72–0.98).0369% (<.001)
Lactobacillus plantarum 299V54530.73 (0.59–0.92).00759% (.04)
All Bifidobacterium strains511610.82 (0.67–1.02).0774% (.004)
Bifidobacterium bifidum MIMBb7525650.69 (0.46–1.04).0783% (.01)
 All Bacillus strains32160.44 (0.34–0.57)<.0010% (.48)
All Saccharomyces strains24690.94 (0.80–1.11).490% (.86)
 All Escherichia strains24180.86 (0.79–0.93)<.0010% (.78)
All Blautia strains13660.93 (0.84–1.03).15N/A
 All Clostridium strains12000.80 (0.64–0.99).04N/A
 All Streptococcus strains1540.72 (0.53–0.99).04N/A
Patients with IBS-D
 All combination probiotics1312720.78 (0.67–0.92).00269% (<.001)
VSL#32490.42 (0.04–4.85).4982% (.02)
Duolac 7s2760.62 (0.43–0.89).0090% (.62)
 All Lactobacillus strains41570.57 (0.36–0.89).0127% (.25)
All Saccharomyces strains21690.99 (0.76–1.28).920% (.81)
 All Clostridium strains12000.80 (0.64–0.99).04N/A
 All Blautia strains12020.94 (0.82–1.08).36N/A
All Escherichia strains1541.00 (0.57–1.74)1.00N/A
All Bifidobacterium strains1440.64 (0.36–1.16).14N/A
All Bacillus strains1400.57 (0.31–1.05).07N/A
Patients with IBS-C
All combination probiotics42951.01 (0.89–1.14).878% (.35)
 All Saccharomyces strains11800.82 (0.62–1.08).16N/A
All Blautia strains11640.92 (0.78–1.07).26N/A
All Escherichia strains1350.84 (0.41–1.73).64N/A

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