This post started from reading “Dietary quality and the gut microbiome in early-stage Parkinson’s disease patients [2023]”. I posted on some Facebook groups “People often are obsessives with getting high Lactobacillus and Bifidobacterium. The “dividend” of this desire appears to be increased risk of Parkinson’s disease.“
The question arises, what other conditions are associated with high levels of both of these? Fortunately, this can be obtained from the Microbiome Prescription databases.
- Amyotrophic lateral sclerosis (ALS) Motor Neuron
- Autism
- Crohn’s Disease
- Depression
- Graves’ disease
- Inflammatory Bowel Disease
- Irritable Bowel Syndrome
- Juvenile idiopathic arthritis
- Liver Cirrhosis
- Long COVID
- Metabolic Syndrome
- Mood Disorders
- Multiple Sclerosis
- Obesity
- Parkinson’s Disease
- Psoriasis
- rheumatoid arthritis (RA),Spondyloarthritis (SpA)
- Schizophrenia
- Stress / posttraumatic stress disorder
- Type 2 Diabetes
- Ulcerative colitis
I also pulled the studies where the study specifically cited both are high. The above list were occasionally from taking data from two different studies.
- A prospective longitudinal study on the microbiota composition in amyotrophic lateral sclerosis [2020]
- The Impact of Microbiota on the Pathogenesis of Amyotrophic Lateral Sclerosis and the Possible Benefits of Polyphenols. An Overview [2021]
- The Role of Gut Microbiota in Gastrointestinal Symptoms of Children with ASD [2019]
- Increased proportions of Bifidobacterium and the Lactobacillus group and loss of butyrate-producing bacteria in inflammatory bowel disease [2014]
- Gut Microbiota in Anxiety and Depression: Unveiling the Relationships and Management Options [2023]
- Gut microbiome in chronic rheumatic and inflammatory bowel diseases: Similarities and differences [2019]
- IBS-associated phylogenetic unbalances of the intestinal microbiota are not reverted by probiotic supplementation [2012]
- Gut microbiota in pre-clinical rheumatoid arthritis: From pathogenesis to preventing progression [2023]
- A Metagenomic Meta-analysis Reveals Functional Signatures of Health and Disease in the Human Gut Microbiome [2019]
- Reversion of Gut Microbiota during the Recovery Phase in Patients with Asymptomatic or Mild COVID-19: Longitudinal Study [2021]
- Composition, taxonomy and functional diversity of the oropharynx microbiome in individuals with schizophrenia and controls [2015]
- Changes of Colonic Bacterial Composition in Parkinson’s Disease and Other Neurodegenerative Diseases [2018]
- Meta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation [2021]
- Inflammatory microbes and genes as potential biomarkers of Parkinson’s disease [2022]
- Metagenomics of Parkinson’s disease implicates the gut microbiome in multiple disease mechanisms [2022]
- Altered fecal microbiota composition in all male aggressor-exposed rodent model simulating features of post-traumatic stress disorder [2018]
- Intestinal flora alterations in patients with ulcerative colitis and their association with inflammation [2021]
- The Gut Microbiome in Parkinson’s Disease: A Longitudinal Study of the Impacts on Disease Progression and the Use of Device-Assisted Therapies [2022]
Bottom Line
A responsible medical professional would test a patient’s Lactobacillus and Bifidobacterium levels before suggesting probiotics to a patient. If your MD makes that recommendation without testing and you have any of the above conditions — it may be time to file a complaint with their supervisors or governing body citing the studies.
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