This study Microbial patterns in patients with histamine intolerance. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2018 reports low Bifidobacteriaceae (NCBI:31953). The Artificial Intelligence Algorithms on Microbiome Prescription (and most medical professionals) would suggest Bifidobacterium probiotics as a possible treatment. Unfortunately, very few medical professionals outside of Poland would have read the above study!

I decided to look at the literature to see if the AI suggestions have been validated by actual studies. This is a few of the studies that I found (the ones where the title alone is sufficient):

• Combined IgE neutralization and Bifidobacterium longum supplementation reduces the allergic response in models of food allergy. [2022]
• Bifidobacterium longum IM55 and Lactobacillus plantarum IM76 alleviate allergic rhinitis in mice by restoring Th2/Treg imbalance and gut microbiota disturbance. [2019]
• Expression and Purification of Extracellular Solute-Binding Protein (ESBP) in Escherichia coli, the Extracellular Protein Derived from Bifidobacterium longum KACC 91563.[2019] ” it was demonstrated that the protein effectively alleviated food allergy symptoms via mast cell specific apoptosis, “
• Post-sensitization administration of non-digestible oligosaccharides and Bifidobacterium breve M-16V reduces allergic symptoms in mice. [2016]
• Three Novel Candidate Probiotic Strains with Prophylactic Properties in a Murine Model of Cow’s Milk Allergy [2016] One of these was Bifidobacterium longum subsp. infantis
• Extracellular vesicle-derived protein from Bifidobacterium longum alleviates food allergy through mast cell suppression.[2016]
• Longitudinal study of effects of oral dosage of Bifidobacterium bifidum G9-1 on Japanese cedar pollen-induced allergic nasal symptoms in guinea pigs. [2015]
• Bifidobacterium breve and Lactobacillus rhamnosus treatment is as effective as budesonide at reducing inflammation in a murine model for chronic asthma.[2014]
• The combination of Bifidobacterium breve with non-digestible oligosaccharides suppresses airway inflammation in a murine model for chronic asthma.[2014]
• Bifidobacterium longum lysate, a new ingredient for reactive skin. [2010]
• Effect of oral probiotics (Bifidobacterium lactis AD011 and Lactobacillus acidophilus AD031) administration on ovalbumin-induced food allergy mouse model. [2008]

Bottom Line

Bifidobacterium Longum appears to be the best researched and easily available as a single species. Different species of probiotics can cause a different response — so keep to single species probiotics and avoid probiotic mixtures as a general rule. My personal favorite source is Custom Probiotics (no financial interest), they are:

• by far the cheapest per BCFU,
• his recommended daily dosages are at therapeutic levels (80- 320 BCFU per day)
• his recommended method of taking is, IMHO, the correct way: NOT IN CAPSULES, but in a glass of water so it impacts the entire system from the mouth downwards (see 24 Years of ME/CFS with Mouth Microbiome for more information and studies)

Watch out for shooting yourself in the Microbiome!

Often I have encounter people frustrated over their inability to increase bifidobacterium or Lactobacillus. When they disclose what they are also taking — it becomes apparent why!

Going to Details about Bifidobacterium: NCBI 1678 we see what increases or decrease it. You may wish to consider reducing or eliminating these items.

General Substance	Specific Substance	Effect
Herb or Spice	ascophyllum nodosum (sea weed)	Studies report Decreases in consensus
Herb or Spice	berberine	Studies report Decreases in consensus
Herb or Spice	Curcumin	Studies report Decreases in consensus
Herb or Spice	galla chinensis (herb)	Studies report Decreases in consensus
Herb or Spice	garlic (allium sativum)	Studies report Decreases in consensus

General Substance	Specific Substance	Effect
Amino Acid and similar	Leonurine	Studies report Decreases in consensus
Amino Acid and similar	melatonin supplement	Studies report Decreases in consensus

General Substance	Specific Substance	Effect
Diet Style	animal-based diet	Studies report Decreases in consensus
Diet Style	gluten-free diet	Studies report Decreases in consensus
Diet Style	high beef diet	Studies report Decreases in consensus
Diet Style	high-fat diets	Studies report Decreases in consensus
Diet Style	high-protein diet	Studies report Decreases in consensus
Diet Style	high-saturated fat diet	Studies report Decreases in consensus
Diet Style	lacto-ovo-vegetarian diet	Studies report Decreases in consensus
Diet Style	low carbohydrate diet	Studies report Decreases in consensus
Diet Style	low fodmap diet	Studies report Decreases in consensus
Diet Style	low-fat diets	Studies report Decreases in consensus
Diet Style	magnesium-deficient diet	Studies report Decreases in consensus

General Substance	Specific Substance	Effect
Vitamins, Minerals and similar	Ferric citrate	Studies report Decreases in consensus
Vitamins, Minerals and similar	fluorine (i.e. tooth paste)	Studies report Decreases in consensus
Vitamins, Minerals and similar	folic acid,(supplement Vitamin B9)	Studies report Decreases in consensus
Vitamins, Minerals and similar	pyridoxine hydrochloride (vitamin B6)	Studies report Decreases in consensus
Vitamins, Minerals and similar	retinoic acid,(Vitamin A derivative)	Studies report Decreases in consensus
Vitamins, Minerals and similar	thiamine hydrochloride (vitamin B1)	Studies report Decreases in consensus
Vitamins, Minerals and similar	Vitamin B-12	Studies report Decreases in consensus
Vitamins, Minerals and similar	vitamin b3 (niacin)	Studies report Decreases in consensus
Vitamins, Minerals and similar	vitamin b7 biotin (supplement) (vitamin B7)	Studies report Decreases in consensus
Vitamins, Minerals and similar	Vitamin C (ascorbic acid)	Studies report Decreases in

The beef/protein diet are high in B-vitamins – thus very logical that both groups decreases.