It has been a year since I had Covid-19 I started to deteriorate after it and fell into a limbo of not having the energy to do anything and move on with treatment, I have gave up supplements, antibiotics, probiotics not taking anything, even if I had them in stock, pretty dire, even had very dark thoughts from nowhere that life is not worth living. I got cervical instability diagnosis in 2020 and the Covid-19 infection that made me abandon the microbiome manipulation road, a very bad decision when I look back now. I got diagnosed with a possible mast cell disorder, MCAS is much more worse then CFS, I got a reaction in airport in September 2022 wanted to travel to Italy for a consultation, reacted to fumes in airport was unable to board the plane, almost called the ambulance, the MCAS appeared after Covid-19. I am taking a H1 and H2 for it, and used to take sodium cromoglicate but I got insomnia from it, doctor here told me I am the first patient that has gotten insomnia from sodium cromoglicate. The interesting thing my cognition improved but my physical state deteriorated, I got POTS.
I have also started a YouTube channel to share my story and to keep me motivated to continue:
To recap what Covid-19 in 2022 infection gave me and I still have:
- -Lack of motivation
- -New food intolerances
- -Reaction to the environment(possible MCAS)
- -Easy bruising(now afraid to take “thick blood” supplements)
- -High cholesterol and triglycerides
Questions from Reader
First, the site does not diagnosis — it is based on association. What is association? It just means that two things tend to happen at the same time. Sometimes there is a real connection — other times the connection is due to other factors. For example, the number of children in a family has declined over the last 50 years. The usage of the internet has increased. There is a statistical association between the two but it does not mean that internet use causes less kids, nor does it mean that having less kids mean more internet use (which may actually be true!).
- Does it show I have POTS, I attached my CellTrend result which is positive for POTS
- You only have a 10% match to bacteria seen in other people who have reported POTS. So, if it is POTS, it is likely atypical POTS.
- I do NOT see on the CellTrend results any thing about POTS. Was it a MD’s opinion based on ???
- Does it give avoid food all casein and lactose foods and nuts, I have attached my IgG intolerances testing
- No, it does not deal will allergies. It suggests food that are likely to positively or negatively impacts the complete microbiome.
Going over to Special Studies, COVID Long Hauler leaps out!! It is the best description of the current state. This appears to be common pattern of ME/CFS people Post COVID: The signature of Long COVID dominates over ME/CFS. This may be due to the variation of bacteria over time with ME/CFS. With a recent case of COVID, there is much less variation and thus a stronger signature is found.
Looking at the distribution of bacteria by percentile, we do not see the count for each range being close to each other (expected result for a “normal’ microbiome). The 0-9% is only 32% instead of expected 10%, which is less than other samples that I have seen at 60%.
|0 – 9||72||79|
|10 – 19||17||28|
|20 – 29||14||15|
|30 – 39||20||32|
|40 – 49||24||24|
|50 – 59||20||22|
|60 – 69||13||20|
|70 – 79||14||19|
|80 – 89||9||7|
|90 – 99||8||12|
Below this on the page (added on April 1, 2023) are “Likely Key Bacteria Causing Above”
|species||Faecalibacterium prausnitzii (in prior)||3.4|
|genus||Faecalibacterium (in prior)||3.3|
|genus||Roseburia (in 2021)||2.3|
|species||Roseburia faecis (in 2021)||1.8|
Looking at trend over 4 samples, we see the dramatic jump in the %age of bacteria that are under 10%ile.
|Lab Read Quality||11||3.3||3.6||3|
|Bacteria Reported By Lab||808||476||632||463|
|Bacteria Over 99%ile||1||5||1||20|
|Bacteria Over 95%ile||15||31||17||55|
|Bacteria Over 90%ile||28||54||48||88|
|Bacteria Under 10%ile||280||18||6||50|
|Bacteria Under 5%ile||246||5||0||35|
|Bacteria Under 1%ile||226||1||0||16|
|Percent Under 10%ile||35%||4%||1%||11%|
|Rarely Seen 1%||6||2||3||1|
|Rarely Seen 5%||37||10||20||18|
|Outside Range from JasonH||5||5||6||6|
|Outside Range from Medivere||17||17||13||13|
|Outside Range from Metagenomics||6||6||7||7|
|Outside Range from MyBioma||3||3||9||9|
|Outside Range from Nirvana/CosmosId||18||18||20||20|
|Outside Range from XenoGene||34||34||37||37|
|Outside Lab Range (+/- 1.96SD)||2||10||7||23|
|Condition Est. Over 99%ile||1||4||2||14|
|Condition Est. Over 95%ile||1||8||5||26|
|Condition Est. Over 90%ile||4||8||7||36|
|Enzymes Over 99%ile||0||55||0||51|
|Enzymes Over 95%ile||14||144||13||133|
|Enzymes Over 90%ile||91||186||60||231|
|Enzymes Under 10%ile||218||62||92||552|
|Enzymes Under 5%ile||161||17||37||408|
|Enzymes Under 1%ile||86||0||2||163|
|Compounds Over 99%ile||0||43||0||28|
|Compounds Over 95%ile||17||95||13||79|
|Compounds Over 90%ile||65||145||43||128|
|Compounds Under 10%ile||1104||983||960||958|
|Compounds Under 5%ile||1088||977||950||934|
|Compounds Under 1%ile||1067||975||948||913|
To build a consensus, I will do.
- Standard Lab Ranges (+/- 2 Std Dev)
- Box Plot Whisker
- Kaltoft-Moltrup Normal Ranges
- “Likely Key Bacteria Causing Above”
This now rolled into a single click! “Just give me suggestions” – It results in the short dumb down list with links to the full details. See the video below.
The suggestions are attached:
- Melatonin, NAC, Quercetin
- Gluten Free Diet, low carbohydrate diet
- Antibiotics ( metronidazole, azithromycin) with 2nd choices being (doxycycline, Rifaximin (Xifaxan))
- Echinacea, Flaxseed, Piperine, Turmeric, Whey (non denatured), Black Cumin, Garlic, Glycyrrhizin/Pure Licorice, Wormwood, chitosan
- Gum Arabic, Racetams, Vinpocetine, lactobacillus brevis, lactobacillus gasseri, Mutaflor e.coli probiotics (Germany), symbioflor 2 e.coli probiotics (Germany)
- E.Coli probiotics was on the top of the KEGG computed probiotics. All of the other suggested were also on the KEGG recommendations.
- Selenium, Magnesium Most of the B-vitamins but not Vitamin B2 Riboflavin
The detail lists are below
That’s enough for Now
I could start digging into the symptoms and other issues cited above, but with the Long COVID signature being so strong let us not over-engineer. We have a course for the first leg of recovery.
Postscript – and Reminder
I am not a licensed medical professional and there are strict laws where I live about “appearing to practice medicine”. I am safe when it is “academic models” and I keep to the language of science, especially statistics. I am not safe when the explanations have possible overtones of advising a patient instead of presenting data to be evaluated by a medical professional before implementing.
I cannot tell people what they should take or not take. I can inform people items that have better odds of improving their microbiome as a results on numeric calculations. I am a trained experienced statistician with appropriate degrees and professional memberships. All suggestions should be reviewed by your medical professional before starting.
The answers above describe my logic and thinking and is not intended to give advice to this person or any one. Always review with your knowledgeable medical professional.