This is a change from the usual microbiome. The microbiome has impact on getting cancers and on the effectiveness of various treatments. A little bit of recent literature is below.
- Colorectal cancer (CRC) is associated with gut microbiota dysbiosis. [2022]
- The role of the bacterial microbiome in the treatment of cancer [2021]
- Role of the Microbiome in Immunotherapy of Melanoma. [2023]
- Defining the Role of the Gut Microbiome in the Pathogenesis and Treatment of Lymphoid Malignancies.[2023]
- Breast cancer patients from the Midwest region of the United States have reduced levels of short-chain fatty acid-producing gut bacteria. [2023]
- Examining the Role of Microbiota-Centered Interventions in Cancer Therapeutics: Applications for Urothelial Carcinoma. [2023]
- Prospect of bacteria for tumor diagnosis and treatment. [2023]
Analysis
This person is atypical — they find the markers for cancer, but cannot locate where it is.
We see a large number of bacteria with only token representation (0-9 Percentile). Statistically, you would expect each of the ranges below to have similar numbers.
| Percentile | Genus | Species |
| 0 – 9 | 73 | 91 |
| 10 – 19 | 16 | 14 |
| 20 – 29 | 14 | 21 |
| 30 – 39 | 19 | 20 |
| 40 – 49 | 12 | 21 |
| 50 – 59 | 16 | 18 |
| 60 – 69 | 8 | 23 |
| 70 – 79 | 11 | 27 |
| 80 – 89 | 33 | 20 |
| 90 – 99 | 22 | 32 |
The new feature “Likely Key Bacteria Causing Above’ show items of concern:
| Rank | Bacteria | Importance |
|---|---|---|
| genus | Megasphaera | 2.6 |
| species | Megasphaera elsdenii | 2.5 |
| genus | Klebsiella | 2.2 |
| species | Klebsiella oxytoca | 2.1 |
| genus | Bifidobacterium | 1.9 |
From the Potential Medical Conditions Detected, we see gut disturbances (Gastroesophageal reflux disease (Gerd) including Barrett’s esophagus, Histamine Issues,Mast Cell Issue, DAO Insufficiency) as well as neurological impacts (Brain Trauma, Epilepsy).
Looking at Bacteria deemed Unhealthy, we have the following with significant counts and percentiles.
| Name | Rank | Percentile | Count | Comment | More Info |
|---|---|---|---|---|---|
| Collinsella | genus | 98 | 15880 | proinflammatory | Citation |
| Enterobacter | genus | 98 | 12700 | Urinary and respiratory infections | Citation |
| Klebsiella | genus | 100 | 74750 | Pathogen | Citation |
| Parabacteroides merdae | species | 94 | 24150 | Infectious bacteria | Citation |
| Prevotella copri | species | 76 | 1990 | Over 70%ile Indicator of mycotoxin present | Citation |
| Salmonella enterica | species | 98 | 600 | Salmonellosis | Citation |
The Prevotella copri may indicate a mold/fungi issue in the house, or it could be a side effect of the immune system being impacted by treatment.
Dr. Jason Hawrelak Recommendations is at 89%ile with the main items well out of range being:
- Akkermansia – too low
- Blautia – too high
- Proteobacteria – too high (specifically Gammaproteobacteria)
- Faecalibacterium prausnitzii – too low
Going Forward
Doing consensus building with following criteria:
- Standard Lab Ranges (+/- 2 Std Dev) – 21 bacteria
- Box Plot Whisker – 53 bacteria
- Kaltoft-Moltrup Normal Ranges – 107 bacteria
- Hand picking all of the bacteria cited above -11 bacteria
The new “just give me suggestions” had the following being clear thumbs up:
- Melatonin
- metronidazole
- NAC
- Gluten Free Diet
- high-protein diet
- low carbohydrate diet
- Aspirin
- Arbutin (polyphenol)
- Fisetin
- Guaiacol (polyphenol)
- Hesperidin
- Luteolin
- Turmeric
- Ajwain (Indian Herb)
- etc
Remember they are suggestions — just pick items that you can afford, can get, and that you are happy taking.
The list of items to take was actually surprising. It was a large list with all 4 sets of suggestions saying take (over 110!) . The top items are below
- foeniculum vulgare (Fennel)
- Curcumin
- Vitamin B-12
- syzygium aromaticum (clove)
- Hesperidin (polyphenol)
- garlic (allium sativum)
- nigella sativa seed (black cumin)
- Caffeine
- thiamine hydrochloride (vitamin B1)
- oregano (origanum vulgare, oil)
- Arbutin (polyphenol)
- diosmin,(polyphenol)
- pyridoxine hydrochloride (vitamin B6)
- retinoic acid,(Vitamin A derivative)
- thyme (thymol, thyme oil)
- luteolin (flavonoid)
- kefe cumin (laser trilobum l.)
- neem
On the avoid list we have many items which for other people tend to be on their take list
- Many prebiotics ( galacto-oligosaccharides, arabinoxylan oligosaccharides, inulin )
- high fiber diet (oats, resistant starch)
Going over to the Food site, we see the following items near the top: Kidney, marmite, Cream of Wheat. The main reason is that they are high in B vitamins.
Postscript – and Reminder
I am not a licensed medical professional and there are strict laws where I live about “appearing to practice medicine”. I am safe when it is “academic models” and I keep to the language of science, especially statistics. I am not safe when the explanations have possible overtones of advising a patient instead of presenting data to be evaluated by a medical professional before implementing.
I cannot tell people what they should take or not take. I can inform people items that have better odds of improving their microbiome as a results on numeric calculations. I am a trained experienced statistician with appropriate degrees and professional memberships. All suggestions should be reviewed by your medical professional before starting.
The answers above describe my logic and thinking and is not intended to give advice to this person or any one. Always review with your knowledgeable medical professional.
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