Condition Progression Using the Microbiome

Today I ran some queries to see how many progressions between the conditions that I have could be inferred from the current data. The following were used:

  • The taxon must be exact matches (no parent of a taxa or taxa children)
  • We count the number of times that the taxa shifts are the same direction, or are different
  • Each condition must share at least 10 bacteria.
  • All of the data (with sources) can be found here for people to dig further into relationships.

The results are below for those with 65% the same or more. Some are very expected, some are not

  • Chronic Fatigue Syndrome with
    • ME/CFS with IBS
    • ME/CFS without IBS
    • ME/CFS with IBS vs ME/CFS without IBS DOES NOT SHOW UP because they only have 5 bacteria in common
  • Small Intestinal Bacterial Overgrowth  (SIBO) was not expected with
    • Colorectal Cancer
    • Rheumatoid Arthritis (RA),Spondyloarthritis (SpA)
    • Parkinson’s Disease
    • But expected with Irritable Bowel Syndrome
    • NOTE: Progression from one condition to another condition may be depend on DNA or epigenetics. If there is a high match up, it should be viewed as increased risk that may be mitigated with adjustments of the microbiome.
Condition NameCondition NameSame Direction PercentageDifferent Direction Percentage
Alzheimer’s diseaseChronic Kidney Disease86.713.3
ADHDChronic Kidney Disease85.714.3
Chronic Fatigue SyndromeME/CFS with IBS85.714.3
Chronic Urticaria (Hives)Obesity85.714.3
Chronic Fatigue SyndromeME/CFS without IBS85.214.8
Chronic Urticaria (Hives)obsessive-compulsive disorder84.615.4
Chronic Urticaria (Hives)Ulcerative colitis83.316.7
Colorectal CancerSmall Intestinal Bacterial Overgrowth  (SIBO)83.316.7
Histamine Issues,Mast Cell Issue, DAO Insufficiencyobsessive-compulsive disorder83.316.7
Brain Traumahypertension (High Blood Pressure83.316.7
Allergic Rhinitis (Hay Fever)Chronic Fatigue Syndrome83.316.7
Ankylosing spondylitisRosacea83.316.7
Parkinson’s DiseaseAnorexia Nervosa83.316.7
rheumatoid arthritis (RA),Spondyloarthritis (SpA)Small Intestinal Bacterial Overgrowth  (SIBO)83.316.7
Brain TraumaMultiple Sclerosis81.818.2
Hyperlipidemia (High Blood Fats)Multiple Sclerosis81.818.2
hypertension (High Blood PressureNonalcoholic Fatty Liver Disease  (nafld) Nonalcoholic81.818.2
Graves’ diseaseBipolar Disorder81.818.2
Chronic Urticaria (Hives)Inflammatory Bowel Disease81.318.8
Stress / posttraumatic stress disorderSystemic Lupus Erythematosus80.819.2
ME/CFS without IBSLong COVID8020
Chronic Kidney DiseaseBipolar Disorder8020
Alzheimer’s diseaseMultiple Sclerosis8020
ADHDobsessive-compulsive disorder78.621.4
gallstone disease (gsd)Ulcerative colitis78.621.4
OsteoarthritisLong COVID78.621.4
Systemic Lupus ErythematosusAnorexia Nervosa77.822.2
ADHDMultiple Sclerosis77.322.7
Chronic Urticaria (Hives)Nonalcoholic Fatty Liver Disease  (nafld) Nonalcoholic76.923.1
Parkinson’s DiseaseSmall Intestinal Bacterial Overgrowth  (SIBO)76.923.1
Chronic Urticaria (Hives)Long COVID76.523.5
Gastroesophageal reflux disease (Gerd) including Barrett’s esophagusLong COVID76.523.5
Chronic Kidney DiseaseSystemic Lupus Erythematosus76.223.8
hypertension (High Blood Pressureobsessive-compulsive disorder7624
Inflammatory Bowel DiseaseSmall Intestinal Bacterial Overgrowth  (SIBO)7525
Histamine Issues,Mast Cell Issue, DAO InsufficiencySchizophrenia7525
Multiple SclerosisSmall Intestinal Bacterial Overgrowth  (SIBO)7525
Nonalcoholic Fatty Liver Disease  (nafld) NonalcoholicStress / posttraumatic stress disorder7525
Chronic Kidney DiseaseGraves’ disease7525
gallstone disease (gsd)Nonalcoholic Fatty Liver Disease  (nafld) Nonalcoholic7525
Cerebral PalsyParkinson’s Disease7525
RosaceaType 1 Diabetes7525
Chronic Urticaria (Hives)Crohn’s Disease73.726.3
Chronic Urticaria (Hives)Psoriasis72.727.3
DepressionME/CFS with IBS72.727.3
neuropsychiatric disorders (PANDAS, PANS)Parkinson’s Disease72.727.3
Irritable Bowel SyndromeOsteoarthritis72.727.3
Histamine Issues,Mast Cell Issue, DAO InsufficiencyInflammatory Bowel Disease72.727.3
Chronic Fatigue SyndromeFunctional constipation / chronic idiopathic constipation72.727.3
AsthmaCeliac Disease72.727.3
rheumatoid arthritis (RA),Spondyloarthritis (SpA)Hidradenitis Suppurativa72.727.3
ADHDAlzheimer’s disease72.227.8
Brain TraumaParkinson’s Disease72.227.8
AtherosclerosisHistamine Issues,Mast Cell Issue, DAO Insufficiency7228
Inflammatory Bowel DiseaseUlcerative colitis71.828.2
Chronic Kidney DiseaseStress / posttraumatic stress disorder71.428.6
AtherosclerosisME/CFS with IBS71.428.6
ADHDFunctional constipation / chronic idiopathic constipation71.428.6
Ankylosing spondylitisGastroesophageal reflux disease (Gerd) including Barrett’s esophagus71.428.6
rheumatoid arthritis (RA),Spondyloarthritis (SpA)Rosacea71.428.6
Chronic Kidney DiseaseLong COVID70.629.4
gallstone disease (gsd)rheumatoid arthritis (RA),Spondyloarthritis (SpA)70.629.4
Multiple SclerosisAnorexia Nervosa70.629.4
Inflammatory Bowel DiseaseNonalcoholic Fatty Liver Disease  (nafld) Nonalcoholic70.429.6
hypertension (High Blood PressureInflammatory Bowel Disease7030
Cerebral PalsyLong COVID7030
Chronic Kidney DiseaseCOVID-1969.630.4
Cerebral Palsyobsessive-compulsive disorder69.230.8
Cerebral PalsyPsoriasis69.230.8
Bipolar Disorderobsessive-compulsive disorder69.230.8
ADHDAnorexia Nervosa69.230.8
Alzheimer’s diseaseAnorexia Nervosa69.230.8
Hyperlipidemia (High Blood Fats)rheumatoid arthritis (RA),Spondyloarthritis (SpA)69.230.8
hypertension (High Blood PressureOsteoporosis69.230.8
Inflammatory Bowel DiseaseAnorexia Nervosa69.230.8
Nonalcoholic Fatty Liver Disease  (nafld) NonalcoholicAnorexia Nervosa69.230.8
Nonalcoholic Fatty Liver Disease  (nafld) NonalcoholicUlcerative colitis69.230.8
FibromyalgiaNonalcoholic Fatty Liver Disease  (nafld) Nonalcoholic69.230.8
Chronic Kidney DiseaseNonalcoholic Fatty Liver Disease  (nafld) Nonalcoholic69.230.8
Chronic Kidney DiseaseOsteoporosis69.230.8
Chronic Kidney DiseaseInflammatory Bowel Disease68.831.3
Chronic Kidney DiseaseMultiple Sclerosis68.831.3
gallstone disease (gsd)Irritable Bowel Syndrome68.831.3
ME/CFS with IBSCOVID-1968.831.3
Irritable Bowel SyndromeSmall Intestinal Bacterial Overgrowth  (SIBO)68.831.3
hypertension (High Blood PressureBipolar Disorder68.831.3
Allergic Rhinitis (Hay Fever)Systemic Lupus Erythematosus68.831.3
AtherosclerosisSmall Intestinal Bacterial Overgrowth  (SIBO)68.831.3
Chronic Kidney DiseaseColorectal Cancer68.831.3
Chronic Kidney DiseaseDepression68.431.6
gallstone disease (gsd)COVID-1968.431.6
AtherosclerosisLiver Cirrhosis68.331.7
Ankylosing spondylitisLiver Cirrhosis68.231.8
Celiac DiseaseInflammatory Bowel Disease68.231.8
Functional constipation / chronic idiopathic constipationSchizophrenia68.231.8
Stress / posttraumatic stress disorderUlcerative colitis68.131.9
Ankylosing spondylitisBipolar Disorder67.932.1
Alzheimer’s diseaseParkinson’s Disease67.632.4
Ulcerative colitisLong COVID6733
Osteoarthritisrheumatoid arthritis (RA),Spondyloarthritis (SpA)66.733.3
Alzheimer’s diseaseInsomnia66.733.3
Amyotrophic lateral sclerosis (ALS) Motor NeuronBipolar Disorder66.733.3
Alzheimer’s diseaseBipolar Disorder66.733.3
Anorexia NervosaLong COVID66.733.3
Anorexia Nervosaobsessive-compulsive disorder66.733.3
AsthmaSystemic Lupus Erythematosus66.733.3
ADHDBipolar Disorder66.733.3
Allergic Rhinitis (Hay Fever)Stress / posttraumatic stress disorder66.733.3
ADHDChronic Fatigue Syndrome66.733.3
AcneStress / posttraumatic stress disorder66.733.3
AcneSystemic Lupus Erythematosus66.733.3
AcneLiver Cirrhosis66.733.3
Allergic Rhinitis (Hay Fever)Sjögren syndrome66.733.3
AllergiesType 1 Diabetes66.733.3
Cerebral PalsyAnkylosing spondylitis66.733.3
Chronic Fatigue SyndromeNonalcoholic Fatty Liver Disease  (nafld) Nonalcoholic66.733.3
Cerebral PalsySystemic Lupus Erythematosus66.733.3
Cerebral PalsyInflammatory Bowel Disease66.733.3
Brain TraumaType 2 Diabetes66.733.3
Brain Traumaobsessive-compulsive disorder66.733.3
Brain TraumaIrritable Bowel Syndrome66.733.3
Fibromyalgiaobsessive-compulsive disorder66.733.3
gallstone disease (gsd)Stress / posttraumatic stress disorder66.733.3
Chronic Kidney Diseaseobsessive-compulsive disorder66.733.3
Chronic Urticaria (Hives)Systemic Lupus Erythematosus66.733.3
Crohn’s DiseaseHistamine Issues,Mast Cell Issue, DAO Insufficiency66.733.3
Histamine Issues,Mast Cell Issue, DAO InsufficiencyLiver Cirrhosis66.733.3
InsomniaLong COVID66.733.3
Inflammatory Bowel Diseaseobsessive-compulsive disorder66.733.3
Inflammatory Bowel DiseaseOsteoarthritis66.733.3
Inflammatory Bowel DiseaseME/CFS without IBS66.733.3
ME/CFS with IBSUlcerative colitis66.733.3
ME/CFS without IBSCOVID-1966.733.3
Liver Cirrhosisneuropsychiatric disorders (PANDAS, PANS)66.733.3
Liver CirrhosisME/CFS with IBS66.733.3
Multiple SclerosisMultiple system atrophy (MSA)66.733.3
Liver CirrhosisStress / posttraumatic stress disorder6634
Inflammatory Bowel Diseaserheumatoid arthritis (RA),Spondyloarthritis (SpA)65.934.1
Celiac Diseaseobsessive-compulsive disorder65.734.3
Celiac DiseaseSystemic Lupus Erythematosus65.634.4
Chronic Fatigue SyndromeSchizophrenia65.534.5
hypertension (High Blood PressureCOVID-1965.534.5
ADHDParkinson’s Disease65.434.6
Sjögren syndromeSystemic Lupus Erythematosus65.434.6
Stress / posttraumatic stress disorderobsessive-compulsive disorder65.234.8
rheumatoid arthritis (RA),Spondyloarthritis (SpA)Bipolar Disorder65.234.8
Chronic Fatigue SyndromeParkinson’s Disease65.234.8
AutismBrain Trauma65.234.8
Multiple SclerosisParkinson’s Disease65.234.8
AtherosclerosisIgA nephropathy (IgAN)6535
Chronic Kidney Diseaserheumatoid arthritis (RA),Spondyloarthritis (SpA)6535
Alzheimer’s diseaseGraves’ disease6535