In discussion with readers, interest in non-drug treatment of mast cell and histamine issues is very high. Trying to get traction with the microbiome has not been successful. On how to use Half-Life, see Half-Life: Not the game but supplements! For Arginine and Glutamine, 100mg of each every hour is suggested.

Dosages: Are the maximum deemed safe by an authority, not recommended dosage

• Cinnamon (Cinnamomum cassia): Dosage Information, Half life 6.7 hours
  • Cinnamaldehyde is the main mediator of cinnamon extract in mast cell inhibition [2015]
  • Cinnamon extract inhibits degranulation and de novo synthesis of inflammatory mediators in mast cells [2013]
  • Cinnamon extract reduces symptoms, inflammatory mediators and mast cell markers in murine IL-10(-/-) colitis [2016]
  • Cinnamon reduces inflammatory response in intestinal fibroblasts in vitro and in colitis in vivo leading to decreased fibrosis [2017]
• Resveratrol (Grape Seed Extract) Half Life 3 hours. Dosage: 2gm/day
  • Resveratrol Treatment Prevents Increase of Mast Cells in Both Murine OVA Enteritis and IL-10^-/- Colitis. [2017]
  • Resveratrol inhibits IL-33-mediated mast cell activation by targeting the MK2/3-PI3K/Akt axis. [2019]
  • Resveratrol Is a Natural Inhibitor of Human Intestinal Mast Cell Activation and Phosphorylation of Mitochondrial ERK1/2 and STAT3. [2021]
• Black Pepper (Piper Nigrum) Half life: 15 hours, 420mg/day
  • Piper nigrum extract ameliorated allergic inflammation through inhibiting Th2/Th17 responses and mast cells activation.
• Arginine and Glutamine: Arginine: 6gm/day, 2 hours. Glutamine: 1 hour, 30gm/day
  • Combined arginine and glutamine decrease release of de novo synthesized leukotrienes and expression of proinflammatory cytokines in activated human intestinal mast cells [2013]
  • Combined glutamine and arginine decrease proinflammatory cytokine production by biopsies from Crohn’s patients in association with changes in nuclear factor-kappaB and p38 mitogen-activated protein kinase pathways. [2008]
• Luteolin: 400 mg/day, 5 hours
  • Luteolin inhibits myelin basic protein-induced human mast cell activation and mast cell-dependent stimulation of Jurkat T cells. [2008]
  • Mast cells, T cells, and inhibition by luteolin: implications for the pathogenesis and treatment of multiple sclerosis. [2007]
  • Impact of polyphenols on mast cells with special emphasis on the effect of quercetin and luteolin. [2018]
• Quercetin: 2gm/day, 24 hours
  • Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. [2012]Quercetin and Resveratrol Differentially Decrease Expression of the High-Affinity IgE Receptor (FcεRI) by Human and Mouse Mast Cells. [2022]
  • Inhibitory effect of quercetin on tryptase and interleukin-6 release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line. [2006]
  • Inhibitory effect of quercetin on tryptase and MCP-1 chemokine release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line. [2006]
• Taxifolin: 460 mg/day, 1.3 hours
  • Inhibitory effect of taxifolin on mast cell activation and mast cell-mediated allergic inflammatory response.
• Probiotics
  • See this list or probiotics for allergies

Reflection into the Microbiome

Most of the items above are modifiers on Microbiome Prescription. An interesting experiment is to see which bacteria/taxa are modified in common with the above. Below are the taxa that occurs 6 or 7 times for the above 7 items.

Taxa Name	Rank	Impact	Times Shared
Bacteroidaceae	family	Decreases	7
Lachnospiraceae	family	Major Decrease	6
Desulfovibrionaceae	family	Major Decrease	6
Clostridiaceae	family	Decreases	6
Bacteroides	genus	Decreases	7
Faecalibacterium	genus	Increases	6
Ruminococcus	genus	Decreases	6
Desulfovibrio	genus	Decreases	6
Roseburia	genus	Decreases	6
Eubacteriales	order	Decreases	6
Bacteroides xylanisolvens	species	Decreases	7
Bacteroides caccae	species	Decreases	7
Bacteroides ovatus	species	Decreases	7
Bacteroides uniformis	species	Decreases	7
Bacteroides thetaiotaomicron	species	Decreases	7
Phocaeicola vulgatus	species	Decreases	7

Items that are marked decreases, are likely bacteria you may want to reduce if you have mast cell issues. Faecalibacterium is the one bacteria that you want to increase.

Applying to your microbiome sample

On the [Research Feature] tab. Find this section and click #2

See Video above for the rest of the steps

As always, review your plan with your knowledgeable medical professional before starting. Some substances may be inappropriate for other medical constraints.