I have had a few emails asking if I am over-flagging these issues on MicrobiomePrescription.
![](https://blog.microbiomeprescription.com/wp-content/uploads/2024/07/image-1-1024x104.png)
I used Perplexity.AI to get some numbers…. here is what was reported (with references to sources). Given the typical reasons that people get microbiome samples, the rates appear reasonable.
- The National Institute of Health (NIH) statistics indicate that biofilm formation is present in about 65% of all bacterial infections and approximately 80% of all chronic infections.
- In the context of human health, biofilms are responsible for about 80% of bacterial infections
https://www.perplexity.ai/search/what-percentage-of-microbiome-fLRJ2SghTLCSWDdlo2AGKw#0
- D-lactic acidosis is considered rare in humans overall, but it may be underdiagnosed. Some experts suggest it should be looked for more often in cases of unexplained metabolic acidosis.
- It is most commonly associated with short bowel syndrome (SBS). The incidence of SBS is estimated at approximately 2 persons per million per year. While not all SBS patients develop D-lactic acidosis, they are at higher risk.
- In patients with short bowel syndrome, D-lactic acidosis appears to be a relatively frequent complication. One study found that all 29 SBS patients examined had experienced neurologic symptoms associated with D-lactic acidosis at some point
[NOTE: SBS have a very high incidence of SIBO [src], so SIBO likely have an increased risk of d-lactic].
https://www.perplexity.ai/search/what-percentage-of-microbiome-fLRJ2SghTLCSWDdlo2AGKw#1
- Histamine intolerance is estimated to affect approximately 1-3% of the general population. However, some experts suggest this number could be higher as the condition is often underdiagnosed.
- Among people with digestive symptoms or conditions like IBS, IBD, and Crohn’s disease, a surprisingly high 30-55% may have histamine intolerance.
- One study found that diamine oxidase (DAO) deficiency, which is associated with histamine intolerance, was present in up to 44% of the control population.
- A more dramatic estimate suggests that histamine intolerance may affect 50-60% of the population, according to one source. However, this figure seems significantly higher than other estimates and may need further verification.
- In people with digestive symptoms, one study showed that 30-55% also have histamine intolerance.
- https://www.perplexity.ai/search/what-percentage-of-microbiome-fLRJ2SghTLCSWDdlo2AGKw#2
Recent Comments