Probiotics impacting diamine oxidase (DAO)

People with mast cell issues typical treatment approach is:

  • Reduce foods high in histamine
  • Avoid probiotics that produces histamine
  • Use DAO supplements.

There is a fourth leg that should be added to this three legged stool. Probiotics (and other substances) that impacts DAO levels. Some could argue that they impact DAO because they produce histamines. That may be true in some rare cases, but many of the items listed below are not known to produce histamine.

More information on PubMed: Histamine Intolerance-The More We Know the Less We Know. A Review [2021].

The production and activity of DAO can be regulated by various factors, including hormones, inflammatory mediators, and the presence of substrates like histamin. Difference probiotics produces different enzymes which may inhibit or assist with the production of DAO.

The probiotics, impact and study used are listed below:

Reviewing the studies is recommended. In some cases DAO levels were raised due to infection, i.e. Escherichia coli K88; and the probiotic may be inhibiting the increase due to the infection though reducing the infection and not actually impacting DAO levels.

Other Common Supplements and DAO or Histamine

Niacin

What is needed are control studies measuring DAO levels in humans with different probiotics. The above illustrates that probiotics are likely to make good or bad differences.