These are notes in progress. Use them at your own risk

In terms of KEGG data, one enzyme stands out: ATP:L-threonine O3-phosphotransferase (2.7.1.177). This is referred to as L-threonine in simpler terms. The people with this sensitivity has 10% of the levels of people not reporting it and there is a value for almost every sample.

This lead to this interest quote (dealing with plants)

• “Salicylic acid[SA] .. in the rhizosphere may be strongly reduced, or completely abolished, due to the presence of histidine and threonine in the root exudates.” [2014] in other threonine may be a key chemical is processing SA.

Checking for the bacteria known to produce the EC2.7.1.177 ATP:L-threonine O3-phosphotransferase the top 3 are:

• Clostridium difficile [species] at 639
• Veillonella dispar [species] at 554
• Megamonas funiformis [species] at 534
• Megasphaera elsdenii [species] at 392

There are no probiotics that produces it. It is available as a supplement, with WebMd suggests this dosage of “Early research suggests that taking 1.5 grams to 2 grams of threonine by mouth three times daily might improve some symptoms in people with familial spastic paraparesis. But the improvement does not seem to be very significant.”

I was unable to find anyone trying this for Salicylate Sensitivity (Hint: any volunteers?)

Salicylate Issues

I did an analysis looking at the frequency percentage of a bacteria being found for Biomesight samples (the largest collection). The key items are below. The higher the Chi² value, the more likely it is.

Tax_Name	Tax_Rank	WithCondition	NoCondition	Chi2
Oceanospirillaceae	family	51.7 (Over)	24.9	8.18
Ruminococcus callidus	species	24.1 (Under)	56.3	5.3
Macrococcus (in Staphylococcaceae family)	genus	58.6 (Over)	35.7	4.16
Amedibacillus	genus	96.6 (Over)	66.7	3.81

There was not sufficient data on Ombre samples

The substances that reduces these overgrowths are: Cacao, green tea, kefir, lychee fruit,  papaya, rhubarb, rosehip tea,  trametes versicolor(Turkey tail mushroom), Slippery Elm. Many of these are low in salicylate (check each one before doing).

Histamine Issues

I did an analysis looking at the frequency percentage of a bacteria being found for Biomesight samples (the largest collection). The statistically significant items are below, with 1 overgrowth “Streptococcus oralis” and the rest as undergrowth . The higher the Chi² value, the more likely it is.

Tax_Name	Tax_Rank	WithCondition	NoCondition	Chi2
Clostridium chartatabidum	species	16.5	29.4	6.54
Euryarchaeota	phylum	14.9	26.9	6.29
Methanobacteriaceae	family	14.9	26.3	5.75
Streptococcus oralis subsp. tigurinus	subspecies	57.9	43.7	5.13
Heliobacteriaceae	family	30.6	44.1	4.8
Ruminococcus callidus	species	42.1	56.7	4.31
Bifidobacterium asteroides	species	20.7	31.4	4.29
Thermosediminibacterales	order	27.3	38.5	3.82

Tax_Name	Tax_Rank	WithCondition	NoCondition	Chi2
Actinopolysporales	order	38.8	24.1	8.83
Anaeroplasmataceae	family	50.9	34.4	7.77
Desulfocella	genus	43.1	28.6	7.26
Desulfocella halophila	species	42.2	28.3	6.8
Rhodocyclales	order	45.7	31.8	6
Burkholderiaceae	family	42.2	29.3	5.77
Spirosomaceae	family	74.1	56.8	5.35
Rothia mucilaginosa	species	19	31.4	5.33
Ruminococcus gauvreauii	species	47.4	34	5.28
Rhodocyclaceae	family	44	31.2	5.19
Ezakiella	genus	39.7	28	4.85
Holdemania massiliensis	species	44	31.7	4.71
Limosilactobacillus	genus	38.8	27.6	4.62
Cytophagaceae	family	85.3	68.1	4.47
Bacteroides fluxus	species	69	53.6	4.45
Halobacteroidaceae	family	44.8	32.9	4.44
Oscillibacter valericigenes	species	44.8	32.9	4.37
Senegalimassilia	genus	44.8	32.9	4.35
Flammeovirgaceae	family	42.2	31.1	4.03
Hungateiclostridium	genus	56.9	43.8	3.95