Special Study: Neurocognitive: Brain Fog

This is reported often in samples, and thus being examined if it reaches our threshold for inclusion as defined in A new specialized selection of suggestions links.

This is now available on the Special Studies

Study Populations:

SymptomReferenceStudy
Neurocognitive:Brain Fog1020127
  • Bacteria Detected with z-score > 2.6: found 97 items, highest value was 5.3
  • Enzymes Detected with z-score > 2.6: found 309 items, highest value was 5.6
  • Compound Detected with z-score > 2.6: found 571 items, highest value was 5.8

Interesting Significant Bacteria

The top item happens to have probiotics that are known to take up residency – Symbioflor-2 and Mutaflor. All of these top items are too low levels

BacteriaReference MeanStudyZ-Score
Escherichia coli (species)7431685.3
Lactiplantibacillus pentosus (species)123255.1
Shuttleworthia (genus)288955.1
Escherichia (genus)590315004.5
Veillonella (genus)407225224.4
Veillonella dispar (species)8531274.4
Staphylococcus pseudolugdunensis (species)46204.2
Clostridium cellulovorans (species)40184.1

Interesting Enzymes

NADH is available as a supplement. It is reported to improve ME/CFS

EnzymeReference MeanStudy
Mean
Z-Score
3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating) (1.14.12.19)6111325.6
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate:NAD+ oxidoreductase (1.3.1.87)5981315.6
propanoyl-CoA:oxaloacetate C-propanoyltransferase (thioester-hydrolysing, 1-carboxyethyl-forming) (2.3.3.5)15144435.2
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase (succinate-forming) (4.1.3.30)14674185.2
[cysteine desulfurase]-S-sulfanyl-L-cysteine:[molybdopterin-synthase sulfur-carrier protein]-Gly-Gly sulfurtransferase (2.8.1.11)542126625.1
ATP:D-tagatose 6-phosphotransferase (2.7.1.101)4221115

Interesting Compounds

All of the top compounds had lower levels

NamesZ-Score
2-Phospho-4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol (C11436)5.8
O-Acetyl-L-homoserine (C01077)5.4
Adenosine-GDP-cobinamide (C06510)5.4
6-Deoxy-L-galactose (C01019)5.2
[Enzyme]-cysteine (C15811)5.2
Adenosyl cobyrinate a,c diamide (C06506)5.1
Xanthosine 5′-phosphate (C00655)5.1
dTDP-glucose (C00842)5.1

Bottom Line

The z-scores for bacteria are lower than Long COVID which reflect the diffusion of bacteria over time. Trying to tackle at the compound or enzyme levels becomes excessively complex. Working at the bacteria level appears viable, but do not expect as many bacteria matches to appear.

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