We have two self reported symptoms with sufficient samples to explore associations:

• Comorbid: Histamine or Mast Cell issues
• Official Diagnosis: Mast Cell Dysfunction

I have done simplified tables below. One item that was very interesting is that some Bifidobacterium was too high and others too low. Of the four low bacteria, only Bifidobacterium breve is available commercially. Low Lactobacillus was not reported anywhere and high Lactobacillales is reported

• Too High
  • Bifidobacteriaceae
  • Bifidobacteriales
  • Bifidobacterium
  • Bifidobacterium adolescentis
  • Bifidobacterium adolescentis JCM 15918
  • Bifidobacterium angulatum
  • Bifidobacterium gallicum
• Too Low
  • Bifidobacterium breve
  • Bifidobacterium catenulatum PV20-2
  • Bifidobacterium catenulatum subsp. kashiwanohense
  • Bifidobacterium cuniculi

Everything below is P < 0.005 (or 1 in 200 of happening at random).

Official Diagnosis: Mast Cell Dysfunction

Biomesight

Bacteria	Rank	Shift
Anaerofustis	genus	Too High
Anaerofustis stercorihominis	species	Too High
Luteibacter	genus	Too Low
Luteibacter anthropi	species	Too Low

Ombre

Bacteria	Rank	Shift
Actinomycetes incertae sedis	no rank	Too High
Comamonadaceae	family	Too High
Deinococci	class	Too High
Deinococcota	phylum	Too High
Desulfocella	genus	Too High
Desulfocella halophila	species	Too High
Emticicia	genus	Too High
Hungateiclostridiaceae	family	Too High
Hungateiclostridium	genus	Too High
Limosilactobacillus	genus	Too High
Limosilactobacillus fermentum	species	Too High
Listeria	genus	Too High
Listeriaceae	family	Too High
Methylococcaceae	family	Too High
Methylococcales	order	Too High
Microbacter	genus	Too High
Neisseriaceae	family	Too High
Neisseriales	order	Too High
Oscillatoriales incertae sedis	no rank	Too High
Paracoccaceae	family	Too High
Pseudoscillatoria	genus	Too High
Pseudoscillatoria coralii	species	Too High
Rickettsia	genus	Too High
Slackia heliotrinireducens	species	Too High
Sphingobacterium	genus	Too High
Staphylococcus	genus	Too High
unclassified Burkholderiales	family	Too High
unclassified Clostridiales	family	Too High
Varibaculum	genus	Too High

Comorbid: Histamine or Mast Cell issues

We have a lot more annotated samples on this self-reported symptoms. There is fuzziness between a pure histamine issue and a mast cell issue

Ombre

Bacteria	Rank	Shift
Absiella tortuosum	species	Too High
Actinomycetes incertae sedis	no rank	Too High
Actinopolysporales	order	Too High
Agaribacter	genus	Too High
Agaribacter marinus	species	Too High
Anaeromicropila	genus	Too High
Anaeromicropila populeti	species	Too High
Blastocatellia	class	Too High
Cerasicoccus frondis	species	Too High
Clostridium grantii	species	Too High
Comamonadaceae	family	Too High
Cryomorphaceae	family	Too High
Deinococci	class	Too High
Deinococcota	phylum	Too High
Desulfitobacteriaceae	family	Too High
Desulfitobacterium	genus	Too High
Desulfobacteriaceae	family	Too High
Desulfocella	genus	Too High
Desulfocella halophila	species	Too High
Desulfofarcimen acetoxidans	species	Too High
Desulfosporosinus	genus	Too High
Desulfuromonadaceae	family	Too High
Desulfuromonadia	class	Too High
Emticicia	genus	Too High
Fusibacter	genus	Too High
Gammaproteobacteria incertae sedis	no rank	Too High
Halopolyspora	genus	Too High
Halopolyspora alba	species	Too High
Holdemania massiliensis	species	Too High
Hydrogenibacillus	genus	Too High
Hydrogenibacillus schlegelii	species	Too High
Limosilactobacillus	genus	Too High
Limosilactobacillus fermentum	species	Too High
Listeria	genus	Too High
Listeriaceae	family	Too High
Mesomycoplasma conjunctivae	species	Too High
Methylococcaceae	family	Too High
Microbacter	genus	Too High
Microbacter margulisiae	species	Too High
Mzabimycetaceae	family	Too High
Neisseriaceae	family	Too High
Neisseriales	order	Too High
Nostocales	order	Too High
Odoribacter laneus	species	Too High
Oscillatoriales incertae sedis	no rank	Too High
Oscillibacter valericigenes	species	Too High
Paracoccaceae	family	Too High
Parasporobacterium	genus	Too High
Pedobacter	genus	Too High
Planctomycetales	order	Too High
Planctomycetia	class	Too High
Planctomycetota	phylum	Too High
Pontibacillus	genus	Too High
Pontibacillus halophilus	species	Too High
Porphyromonas somerae	species	Too High
Propioniferax	genus	Too High
Propioniferax innocua	species	Too High
Proteinivorax tanatarense	species	Too High
Pseudoramibacter	genus	Too High
Pseudoramibacter alactolyticus	species	Too High
Pseudorhodobacter	genus	Too High
Pseudoscillatoria	genus	Too High
Pseudoscillatoria coralii	species	Too High
Rhodocyclaceae	family	Too High
Rhodocyclales	order	Too High
Rickettsia	genus	Too High
Rickettsiaceae	family	Too High
Rickettsiales	order	Too High
Rickettsieae	tribe	Too High
Saccharofermentans	genus	Too High
Saccharofermentans acetigenes	species	Too High
Sedimentibacter	genus	Too High
Sphingobacterium	genus	Too High
spotted fever group	species group	Too High
Stackebrandtia nassauensis	species	Too High
Stomatobaculum	genus	Too High
Texcoconibacillus	genus	Too High
Texcoconibacillus texcoconensis	species	Too High
Thiohalobacter	genus	Too High
Thiohalobacter thiocyanaticus	species	Too High
Thiohalobacteraceae	family	Too High
Thiohalobacterales	order	Too High
Thiohalorhabdaceae	family	Too High
Thiohalorhabdales	order	Too High
Verrucomicrobiaceae	family	Too High
Weeksellaceae	family	Too High

Biomesight

Bacteria	Rank	Shift
Acidaminococcus	genus	Too Low
Acidaminococcus fermentans	species	Too Low
Actinomycetes	class	Too High
Actinomycetota	phylum	Too High
Amedibacillus	genus	Too High
Amedibacillus dolichus	species	Too High
Anaerobranca	genus	Too High
Anaerobranca zavarzinii	species	Too High
Anaerolinea	genus	Too High
Anaerolinea thermolimosa	species	Too High
Anaerolineaceae	family	Too High
Anaerolineales	order	Too High
Anaerotruncus	genus	Too Low
Anaerotruncus colihominis	species	Too Low
Archaea	superkingdom	Too Low
Atopobium fossor	species	Too Low
Azoarcus	genus	Too High
Bacteroidaceae	family	Too Low
Bacteroides	genus	Too Low
Bacteroides acidifaciens	species	Too Low
Bacteroides cellulosilyticus	species	Too Low
Bacteroides fluxus	species	Too Low
Bacteroides uniformis	species	Too Low
Bifidobacteriaceae	family	Too High
Bifidobacteriales	order	Too High
Bifidobacterium	genus	Too High
Bifidobacterium adolescentis	species	Too High
Bifidobacterium adolescentis JCM 15918	strain	Too High
Bifidobacterium angulatum	species	Too High
Bifidobacterium breve	species	Too Low
Bifidobacterium catenulatum PV20-2	strain	Too Low
Bifidobacterium catenulatum subsp. kashiwanohense	subspecies	Too Low
Bifidobacterium cuniculi	species	Too Low
Bifidobacterium gallicum	species	Too High
Bilophila	genus	Too Low
Bilophila wadsworthia	species	Too Low
Blautia	genus	Too Low
Caloramator mitchellensis	species	Too High
Candidatus Tammella caduceiae	species	Too High
Catenibacterium	genus	Too High
Catenibacterium mitsuokai	species	Too High
Cetobacterium	genus	Too High
Chloroflexota	phylum	Too High
Coprococcus	genus	Too High
Coprococcus eutactus	species	Too High
Coraliomargarita	genus	Too High
Coraliomargarita	genus	Too Low
Coraliomargarita akajimensis	species	Too High
Coraliomargarita akajimensis	species	Too Low
Coraliomargaritaceae	family	Too High
Coraliomargaritaceae	family	Too Low
Deferribacter	genus	Too High
Deferribacter autotrophicus	species	Too High
Deferribacteraceae	family	Too High
Deferribacterales	order	Too High
Deferribacteres	class	Too High
Deferribacterota	phylum	Too High
Desulfitobacterium	genus	Too Low
Desulfomonilaceae	family	Too High
Desulfomonilales	order	Too High
Desulfomonilia	class	Too High
Desulforamulus	genus	Too High
Ectothiorhodospira imhoffii	species	Too High
Entomoplasmataceae	family	Too Low
Entomoplasmatales	order	Too Low
Eubacterium limosum	species	Too High
Euryarchaeota	phylum	Too Low
Faecalibacterium	genus	Too High
Fusobacterium nucleatum	species	Too High
Hathewaya	genus	Too Low
Hathewaya histolytica	species	Too Low
Helicobacter	genus	Too High
Helicobacter	genus	Too Low
Helicobacteraceae	family	Too High
Helicobacteraceae	family	Too Low
Holdemanella	genus	Too High
Holdemanella biformis	species	Too High
Holdemania	genus	Too Low
Hoylesella loescheii	species	Too High
Hyphomicrobiales	order	Too High
Hyphomicrobiales	order	Too Low
Johnsonella	genus	Too Low
Johnsonella ignava	species	Too Low
Lachnobacterium	genus	Too High
Lactobacillales	order	Too High
Lactococcus	genus	Too High
Limosilactobacillus	genus	Too Low
Luteibacter	genus	Too High
Luteibacter anthropi	species	Too High
Lysobacter deserti	species	Too High
Mesoplasma	genus	Too Low
Mesoplasma entomophilum	species	Too Low
Methanobacteria	class	Too Low
Methanobacteriaceae	family	Too Low
Methanobacteriales	order	Too Low
Methanobrevibacter	genus	Too Low
Methanobrevibacter smithii	species	Too Low
Methanomada group	clade	Too Low
Mogibacterium vescum	species	Too High
Mollicutes	class	Too High
Mycobacteriaceae	family	Too High
Mycobacterium	genus	Too High
Mycoplasmatota	phylum	Too High
Myxococcales	order	Too High
Myxococcia	class	Too High
Myxococcota	phylum	Too High
Natranaerobiales	order	Too High
Pedobacter	genus	Too Low
Phascolarctobacterium faecium	species	Too Low
Phocaeicola	genus	Too Low
Phocaeicola massiliensis	species	Too High
Phocaeicola paurosaccharolyticus	species	Too Low
Polyangia	subclass	Too High
Prevotella dentasini	species	Too High
Prevotellaceae	family	Too High
Prosthecobacter	genus	Too High
Proteinivoraceae	family	Too High
Ruminococcus callidus	species	Too High
Schaalia naturae	species	Too High
Segatella	genus	Too High
Segatella copri	species	Too High
Segatella paludivivens	species	Too High
Shewanella upenei	species	Too High
Slackia	genus	Too High
Slackia isoflavoniconvertens	species	Too Low
Sphingobium	genus	Too High
Sutterella stercoricanis	species	Too High
Syntrophales	order	Too High
Syntrophia	class	Too High
Syntrophomonadaceae	family	Too High
Thermus	genus	Too High
Thiothrix ramosa	species	Too High

Bottom Line

The above data will eventually be incorporated into the expert system suggestions on Microbiome Prescription.