This is a common symptom for many people with Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This is reported often in samples, and thus being examined if it reaches our threshold for inclusion as defined in A new specialized selection of suggestions links. It does. We are not being specific about the type of allergy.

Sub-Series Study Populations:

We have 5 symptom annotations that this sub-series are examining, I tried different combination to see which resulted in a higher z-score to identify probable siblings (in a statistical sense)

• New food sensitivities – 12.1 z-score
• Medication sensitivities -8.8 z-score
  • Combined, dropped to 6.4
• Alcohol intolerance – 8.6 z-score
  • with Medication sensitivities 8.6 z-score and less bacteria
• Allergic Rhinitis (Hay Fever) – 8.6 z-score
  • When combined with any of the above, a major drop of z-scores
• Allergies – 9.2 z-score
  • With new food sensitivities – 9.9 z-score
  • When combined with any of the other, a major drop of z-scores

We have broken this down into 3 sub-groups of microbiome shifts:

• Allergies and Food Sensitivity
• Alcohol intolerance + Medication sensitivities (this study).
• Allergic Rhinitis (Hay Fever)

Symptom	Reference	Study
Alcohol intolerance + Medication sensitivities	1144	59

• Bacteria Detected with z-score > 2.6: found 130 items, highest value was 8.6
• Enzymes Detected with z-score > 2.6: found 507 items, highest value was 7.9
• Compound Detected with z-score > 2.6: found No items

The bacteria that was most significant was NOT Prevotella copri (species) which we saw with Special Studies: Allergies And Food Sensitivity.

Interesting Significant Bacteria

All bacteria found significant (except 1) had too low levels. This is a common pattern found with these studies, it is not “bad bacteria bogie man bacteria” but an absence of “upstanding citizens bacteria”. The signature is very interesting because it is specific Bifidobacterium species — despite this, the Bifidobacterium genus was not found to be statistically significant. This drops us into the odd space of general Bifidobacterium probiotics likely not be effective, but specific strains may be(unfortunately those strains are not available as probiotics). There is one retail probiotics that contains Enterbacter, General Biotics/Equilibrium which give an experiment to try.

Bacteria	Reference Mean	Study	Z-Score
Bifidobacterium gallicum (species)	3698	136	8.6
Bifidobacterium catenulatum subsp. kashiwanohense (subspecies)	316	55	6.9
Bifidobacterium kashiwanohense PV20-2 (strain)	315	55	6.8
Enterobacter (genus)	1361	127	5.6
Bifidobacterium angulatum (species)	183	20	5.2
Gammaproteobacteria (class)	14010	5636	5
Aeromonadaceae (family)	157	25	5

Interesting Enzymes

All 507 enzymes found significant had too low levels. This places it into the same class of massive enzyme disruptions as seen in Special Studies: Depression . As with that one, apologies for the massive list — I am keeping to my practice for these studies of listing everything with 5.0 z-score or higher.

Enzyme	Reference Mean	Study Mean	Z-Score
2-acetylphloroglucinol C-acetyltransferase (2.3.1.272)	177	28	7.9
[cysteine desulfurase]-S-sulfanyl-L-cysteine:[molybdopterin-synthase sulfur-carrier protein]-Gly-Gly sulfurtransferase (2.8.1.11)	5231	1805	7.7
S-adenosyl-L-methionine:tellurite methyltransferase (2.1.1.265)	5238	1938	7
decenoyl-[acyl-carrier protein] Delta2-trans-Delta3-cis-isomerase (5.3.3.14)	6010	2276	6.9
tRNA-uridine65 uracil mutase (5.4.99.26)	4052	1226	6.8
coproporphyrinogen:oxygen oxidoreductase (decarboxylating) (1.3.3.3)	3163	746	6.8
donor:hydrogen-peroxide oxidoreductase (1.11.1.21)	3030	672	6.7
2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase (5.3.3.18)	3097	1059	6.7
3-hydroxybutanoyl-CoA 3-epimerase (5.1.2.3)	2951	696	6.7
ATP:nicotinamide-nucleotide adenylyltransferase (2.7.7.1)	5076	2200	6.7
ATP:1-(beta-D-ribofuranosyl)-nicotinamide 5′-phosphotransferase (2.7.1.22)	5025	2187	6.6
isocitrate glyoxylate-lyase (succinate-forming) (4.1.3.1)	2955	730	6.6
D-amino acid:quinone oxidoreductase (deaminating) (1.4.5.1)	2485	686	6.5
L-methionine:2-oxo-acid aminotransferase (2.6.1.88)	2759	652	6.5
2-(glutathione-S-yl)-hydroquinone:glutathione oxidoreductase (1.8.5.7)	3140	748	6.5
D-glucose:ubiquinone oxidoreductase (1.1.5.2)	2200	462	6.5
methanesulfonate,FMNH2:oxygen oxidoreductase (1.14.14.34)	2239	489	6.5
alkanesulfonate,FMNH2:oxygen oxidoreductase (1.14.14.5)	2239	489	6.5
glutathione:NADP+ oxidoreductase (1.8.1.7)	5947	2494	6.5
triphosphate phosphohydrolase (3.6.1.25)	4494	2012	6.4
S-(hydroxymethyl)glutathione:NAD+ oxidoreductase (1.1.1.284)	2862	759	6.4
(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase (1.1.1.35)	3374	926	6.4
ferredoxin:NAD+ oxidoreductase (1.18.1.3)	1992	455	6.4
acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase (2.3.1.15)	3270	1139	6.4
S-adenosyl-L-methionine:tRNA (cytidine32/uridine32-2′-O)-methyltransferase (2.1.1.200)	3316	1093	6.3
[50S ribosomal protein L16]-L-Arg81,2-oxoglutarate:oxygen oxidoreductase (3R-hydroxylating) (1.14.11.47)	3334	1114	6.3
choline:acceptor 1-oxidoreductase (1.1.99.1)	2748	562	6.3
acetyl-CoA:glyoxylate C-acetyltransferase [(S)-malate-forming] (2.3.3.9)	3116	950	6.3
siroheme ferro-lyase (sirohydrochlorin-forming) (4.99.1.4)	2565	539	6.2
deoxyribocyclobutadipyrimidine pyrimidine-lyase (4.1.99.3)	4156	1337	6.2
acetyl-CoA:[elongator tRNAMet]-cytidine34 N4-acetyltransferase (ATP-hydrolysing) (2.3.1.193)	3309	1094	6.2
7,8-dihydroneopterin 3′-triphosphate diphosphohydrolase (3.6.1.67)	3607	1299	6.2
n/a (3.4.11.23)	3312	1083	6.2
acetyl-CoA:dTDP-4-amino-4,6-dideoxy-alpha-D-galactose N-acetyltransferase (2.3.1.210)	2766	673	6.2
ATP:N-acetyl-D-glucosamine 6-phosphotransferase (2.7.1.59)	3263	1071	6.2
L-2,4-diaminobutanoate carboxy-lyase (propane-1,3-diamine-forming) (4.1.1.86)	2127	304	6.2
chorismate pyruvate-lyase (4-hydroxybenzoate-forming) (4.1.3.40)	2596	567	6.2
protein dithiol:quinone oxidoreductase (disulfide-forming) (1.8.5.9)	3557	1276	6.2
fatty acyl-[acyl-carrier protein]:alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-[lipid IVA] O-acyltransferase (2.3.1.243)	3322	1097	6.2
ATP:L-threonine O3-phosphotransferase (2.7.1.177)	2358	350	6.1
ditrans-octacis-undecaprenyl-diphosphate:alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid-A phosphotransferase (2.7.4.29)	2852	1008	6.1
D-sorbitol-6-phosphate:NAD+ 2-oxidoreductase (1.1.1.140)	2447	677	6.1
diacylglycerol-3-phosphate phosphohydrolase (3.1.3.4)	3284	1105	6.1
1,2-diacyl-sn-glycerol 3-phosphate phosphohydrolase (3.1.3.81)	3284	1105	6.1
(R)-lactate:quinone 2-oxidoreductase (1.1.5.12)	2328	510	6.1
(S)-lactate:ferricytochrome-c 2-oxidoreductase (1.1.2.3)	2368	544	6.1
methyl DNA-base, 2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming) (1.14.11.33)	2304	475	6.1
ATP:D-ribulose-5-phosphate 1-phosphotransferase (2.7.1.19)	2435	543	6.1
(2S,3S)-2,3-dihydro-2,3-dihydroxybenzoate:NAD+ oxidoreductase (1.3.1.28)	2240	476	6.1
D-mannitol-1-phosphate:NAD+ 5-oxidoreductase (1.1.1.17)	2672	727	6
2-O-(alpha-D-mannopyranosyl)-D-glycerate D-mannohydrolase (3.2.1.170)	1248	396	6
S-formylglutathione hydrolase (3.1.2.12)	2402	554	6
gamma-L-glutamyl-L-cysteinyl-glycine:spermidine amidase (3.5.1.78)	3189	1059	6
gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) [spermidine is numbered so that atom N-1 is in the amino group of the aminopropyl part of the molecule] (6.3.1.8)	3189	1059	6
S-adenosyl-L-methionine:23S rRNA (uracil747-C5)-methyltransferase (2.1.1.189)	3257	1112	6
S-adenosyl-L-methionine:uridine in tRNA 3-[(3S)-3-amino-3-carboxypropyl]transferase (2.5.1.25)	1704	303	6
succinate-semialdehyde:NAD+ oxidoreductase (1.2.1.24)	2416	449	6
Fe(II)-siderophore:NADP+ oxidoreductase (1.16.1.9)	2344	447	6
ATP phosphohydrolase (ABC-type, taurine-importing) (7.6.2.7)	2185	521	6
geraniol:NADP+ oxidoreductase (1.1.1.183)	2470	466	6
ATP:N-acyl-D-mannosamine 6-phosphotransferase (2.7.1.60)	3204	1098	5.9
L-serine:[L-seryl-carrier protein] ligase (AMP-forming) (6.2.1.72)	2199	454	5.9
galactarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming) (4.2.1.42)	3015	963	5.9
propanoyl-CoA:phosphate propanoyltransferase (2.3.1.222)	1738	358	5.9
ATP:thiamine phosphotransferase (2.7.1.89)	2372	492	5.9
ATP phosphohydrolase (ABC-type, putrescine-importing) (7.6.2.16)	2302	503	5.9
ubiquinol:oxygen oxidoreductase (superoxide-forming) (1.10.3.17)	2232	475	5.9
S-adenosyl-L-methionine:23S rRNA (guanine1835-N2)-methyltransferase (2.1.1.174)	2258	485	5.9
riboflavin:NAD(P)+ oxidoreductase (1.5.1.41)	2323	491	5.9
D-erythrose 4-phosphate:NAD+ oxidoreductase (1.2.1.72)	2267	485	5.9
CDP-diacylglycerol phosphatidylhydrolase (3.6.1.26)	2239	499	5.9
D-glucarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming) (4.2.1.40)	2953	1125	5.9
6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming) (4.2.1.12)	2260	495	5.8
ATP:propanoate phosphotransferase (2.7.2.15)	2215	469	5.8
isochorismate pyruvate-hydrolase (3.3.2.1)	2164	473	5.8
(3Z/3E)-alk-3-enoyl-CoA (2E)-isomerase (5.3.3.8)	2225	487	5.8
ATP phosphohydrolase (ABC-type, L-arabinose-importing) (7.5.2.12)	2214	473	5.8
n/a (3.4.24.55)	2279	492	5.8
diacylphosphatidylethanolamine:alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid-A 7”-phosphoethanolaminetransferase (2.7.8.42)	2371	500	5.8
2,3-dihydroxybenzoate:L-serine ligase (6.3.2.14)	2179	611	5.8
2-O-(alpha-D-glucopyranosyl)-D-glycerate:phosphate alpha-D-glucosyltransferase (configuration-retaining) (2.4.1.352)	1217	249	5.8
pyrimidine-5′-nucleotide phosphoribo(deoxyribo)hydrolase (3.2.2.10)	2222	495	5.8
6-sulfo-alpha-D-quinovosyl diacylglycerol 6-sulfo-D-quinovohydrolase (3.2.1.199)	1113	222	5.8
(9Z)-hexadec-9-enoyl-[acyl-carrier protein]:Kdo2-lipid IVA O-palmitoleoyltransferase (2.3.1.242)	2356	502	5.8
[RNA]-adenosine-cytidine 5′-hydroxy-adenosoine ribonucleotide-3′-[RNA fragment]-lyase (cyclicizing; [RNA fragment]-3′-cytidine-2′,3′-cyclophosphate-forming and hydrolysing) (4.6.1.21)	2312	470	5.8
ATP phosphohydrolase (ABC-type, D-allose-importing) (7.5.2.8)	2146	431	5.8
6-methoxy-3-methyl-2-(all-trans-polyprenyl)-1,4-benzoquinol,acceptor:oxygen oxidoreductase (5-hydroxylating) (1.14.99.60)	2180	540	5.8
NADPH:NAD+ oxidoreductase (Si-specific) (1.6.1.1)	2204	490	5.8
taurine, 2-oxoglutarate:oxygen oxidoreductase (sulfite-forming) (1.14.11.17)	2122	496	5.8
(deoxy)cytidine 5′-triphosphate diphosphohydrolase (3.6.1.65)	2307	500	5.7
2-(all-trans-polyprenyl)phenol,NADPH:oxygen oxidoreductase (6-hydroxylating) (1.14.13.240)	2178	535	5.7
dTDP-N-acetyl-alpha-D-fucose:N-acetyl-beta-D-mannosaminouronyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol N-acetylfucosaminyltransferase (2.4.1.325)	2308	507	5.7
ATP:[isocitrate dehydrogenase (NADP+)] phosphotransferase (2.7.11.5)	2142	516	5.7
2,3-dihydroxybenzoate:[aryl-carrier protein] ligase (AMP-forming) (6.2.1.71)	2118	604	5.7
5,6,7,8-tetrahydromonapterin:NADP+ oxidoreductase (1.5.1.50)	2159	476	5.7
glutathione gamma-glutamyl cyclotransferase (5-oxo-L-proline producing) (4.3.2.7)	2158	500	5.7
iron(III)-enterobactin hydrolase (3.1.1.108)	2204	491	5.7
N,N’-diacetylchitobiose acetylhydrolase (3.5.1.105)	2304	508	5.7
N-succinyl-L-glutamate amidohydrolase (3.5.1.96)	2172	518	5.7
protein-Npi-phospho-L-histidine:N-acetyl-D-muramate Npi-phosphotransferase (2.7.1.192)	2283	474	5.7
4-alpha-D-[(1->4)-alpha-D-glucano]trehalose glucanohydrolase (trehalose-producing) (3.2.1.141)	1335	181	5.7
acetyl-CoA:N6-hydroxy-L-lysine 6-acetyltransferase (2.3.1.102)	708	159	5.6
4-aminobutanoate:2-oxoglutarate aminotransferase (2.6.1.19)	3600	1155	5.6
ATP:(S)-4,5-dihydroxypentane-2,3-dione 5-phosphotransferase (2.7.1.189)	1415	220	5.6
inosine/xanthosine 5′-triphosphate phosphohydrolase (3.6.1.73)	2071	496	5.6
6-deoxy-6-sulfofructose-1-phosphate 2-hydroxy-3-oxopropane-1-sulfonate-lyase (glycerone-phosphate-forming) (4.1.2.57)	1346	295	5.6
protein-Npi-phospho-L-histidine:2-O-alpha-mannopyranosyl-D-glycerate Npi-phosphotransferase (2.7.1.195)	1163	234	5.6
2,3-dihydroxypropane-1-sulfonate:NAD+ 3-oxidoreductase (1.1.1.373)	1341	295	5.6
4-aminobutanal:NAD+ 1-oxidoreductase (1.2.1.19)	2237	491	5.6
N-succinyl-L-glutamate 5-semialdehyde:NAD+ oxidoreductase (1.2.1.71)	2135	535	5.6
protein-dithiol:NAD(P)+ oxidoreductase (1.8.1.8)	2151	540	5.6
succinyl-CoA:acetyl-CoA C-succinyltransferase (2.3.1.174)	1445	205	5.6
succinyl-CoA:L-arginine N2-succinyltransferase (2.3.1.109)	2135	536	5.6
3-oxo-5,6-dehydrosuberyl-CoA semialdehyde:NADP+ oxidoreductase (1.2.1.91)	1461	221	5.6
2-oxepin-2(3H)-ylideneacetyl-CoA hydrolase (3.3.2.12)	1461	221	5.6
N2-succinyl-L-arginine iminohydrolase (decarboxylating) (3.5.3.23)	2134	536	5.6
ATP phosphohydrolase (ABC-type, nitrate-importing) (7.3.2.4)	1523	142	5.6
7,8-dihydroneopterin 3′-triphosphate 2′-epimerase (5.1.99.7)	1928	468	5.5
N4-acetylcytidine amidohydrolase (3.5.1.135)	2966	1096	5.5
N2-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase (2.6.1.81)	2254	677	5.5
(1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase (5.4.99.15)	1319	183	5.5
ATP:2-dehydro-3-deoxy-D-galactonate 6-phosphotransferase (2.7.1.58)	1536	299	5.5
2-dehydro-3-deoxy-6-phospho-D-galactonate D-glyceraldehyde-3-phospho-lyase (pyruvate-forming) (4.1.2.21)	1538	299	5.5
(S)-ureidoglycolate:NAD+ oxidoreductase (1.1.1.350)	1729	436	5.5
ATP:D-glyceraldehyde 3-phosphotransferase (2.7.1.28)	1512	115	5.5
ATP:glycerone phosphotransferase (2.7.1.29)	1512	115	5.5
FAD AMP-lyase (riboflavin-cyclic-4′,5′-phosphate-forming) (4.6.1.15)	1512	115	5.5
tRNA 2-(methylsulfanyl)-N6-prenyladenosine37,donor:oxygen 4-oxidoreductase (trans-hydroxylating) (1.14.99.69)	1565	158	5.5
S-methyl-5′-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase (2.4.2.28)	3673	1543	5.4
primary-amine:oxygen oxidoreductase (deaminating) (1.4.3.21)	1495	217	5.4
UDP-4-amino-4-deoxy-alpha-L-arabinose:ditrans,octacis-undecaprenyl phosphate 4-amino-4-deoxy-alpha-L-arabinosyltransferase (2.4.2.53)	2107	573	5.4
(2S)-2-hydroxy-3,4-dioxopentyl phosphate aldose-ketose-isomerase (5.3.1.32)	1529	259	5.4
acyl-CoA:acetyl-CoA C-acyltransferase (2.3.1.16)	3869	1876	5.4
2,3-didehydroadipoyl-CoA:acetyl-CoA C-didehydroadipoyltransferase (double bond migration) (2.3.1.223)	1516	224	5.4
10-formyltetrahydrofolate:UDP-4-amino-4-deoxy-beta-L-arabinose N-formyltransferase (2.1.2.13)	2048	470	5.4
UDP-alpha-D-glucuronate:NAD+ oxidoreductase (decarboxylating) (1.1.1.305)	2048	470	5.4
4-amino-4-deoxy-alpha-L-arabinopyranosyl ditrans,octacis-undecaprenyl-phosphate:lipid IVA 4-amino-4-deoxy-L-arabinopyranosyltransferase (2.4.2.43)	2044	473	5.4
5-(methylsulfanyl)-D-ribulose-1-phosphate 4-hydro-lyase [5-(methylsulfanyl)-2,3-dioxopentyl-phosphate-forming] (4.2.1.109)	1552	181	5.3
UDP-4-amino-4-deoxy-beta-L-arabinose:2-oxoglutarate aminotransferase (2.6.1.87)	2070	480	5.3
phenylacetyl-CoA:oxygen oxidoreductase (1,2-epoxidizing) (1.14.13.149)	1375	278	5.3
ATP phosphohydrolase (ABC-type, D-xylose-transporting) (7.5.2.10)	1473	308	5.3
5-(methylsulfanyl)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing) (3.1.3.77)	1689	121	5.3
N-benzoylamino-acid amidohydrolase (3.5.1.32)	1712	408	5.3
phenylacetaldehyde:NAD+ oxidoreductase (1.2.1.39)	1391	271	5.3
L-glutamate:putrescine ligase (ADP-forming) (6.3.1.11)	1902	448	5.3
iron(III)-salmochelin complex hydrolase (3.1.1.109)	727	159	5.3
2-O-(alpha-D-mannosyl)-3-phosphoglycerate phosphohydrolase (3.1.3.70)	2061	498	5.3
4-(gamma-L-glutamylamino)butanoate amidohydrolase (3.5.1.94)	1914	445	5.3
GDP-alpha-D-mannuronate:mannuronan D-mannuronatetransferase (2.4.1.33)	154	39	5.2
[mannuronan]-beta-D-mannuronate 5-epimerase (5.1.3.37)	154	39	5.2
3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming] (4.1.1.74)	1802	138	5.2
quinate:quinol 3-oxidoreductase (1.1.5.8)	1523	124	5.2
betaine-aldehyde:NAD+ oxidoreductase (1.2.1.8)	2057	434	5.2
catechol:oxygen 2,3-oxidoreductase (ring-opening) (1.13.11.2)	3240	1416	5.2
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one:oxygen oxidoreductase (formate- and CO-forming) (1.13.11.53)	1714	283	5.2
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one:oxygen oxidoreductase (formate-forming) (1.13.11.54)	1714	283	5.2
ATP phosphohydrolase (ABC-type, thiamine-importing) (7.6.2.15)	3503	1300	5.2
citrate:N6-acetyl-N6-hydroxy-L-lysine ligase (AMP-forming) (6.3.2.38)	797	193	5.1
RX:glutathione R-transferase (2.5.1.18)	2968	1025	5.1
N2-citryl-N6-acetyl-N6-hydroxy-L-lysine:N6-acetyl-N6-hydroxy-L-lysine ligase (AMP-forming) (6.3.2.39)	795	193	5.1
putrescine:2-oxoglutarate aminotransferase (2.6.1.82)	3168	1490	5.1
UDP-alpha-D-glucose:enterobactin 5′-C-beta-D-glucosyltransferase (configuration-inverting) (2.4.1.369)	807	200	5.1
4-hydroxybutanoate:NAD+ oxidoreductase (1.1.1.61)	2322	607	5.1
D-xylonate hydro-lyase (2-dehydro-3-deoxy-D-arabinonate-forming) (4.2.1.82)	621	178	5
D-glycerate:NAD(P)+ oxidoreductase (1.1.1.60)	1888	516	5
galactitol-1-phosphate:NAD+ oxidoreductase (1.1.1.251)	997	277	5
alkylmercury mercury(II)-lyase (alkane-forming) (4.99.1.2)	577	115	5
(S)-2-hydroxyglutarate:quinone oxidoreductase (1.1.5.13)	2192	670	5
(R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase (1.1.1.36)	523	154	5

Bottom Line

These two symptoms tend to be ignored by the medical establishment. There are studies on the microbiome impacting the efficiency of prescription drugs but not sensitivities or hyper-reactivity. This means that this post is likely the first study on these in existence.

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