Special Studies: Allergic Rhinitis (Hay Fever)

This is a common symptom for many people. This is reported often in samples, and thus being examined if it reaches our threshold for inclusion as defined in A new specialized selection of suggestions links. It does. We are not being specific about the type of allergy.

Sub-Series Study Populations:

We have 5 symptom annotations that this sub-series are examining, I tried different combination to see which resulted in a higher z-score to identify probable siblings (in a statistical sense)

  • New food sensitivities – 12.1 z-score
  • Medication sensitivities -8.8 z-score
    • Combined, dropped to 6.4
  • Alcohol intolerance – 8.6 z-score
    • with Medication sensitivities 9.9 z-score and less bacteria
  • Allergic Rhinitis (Hay Fever) – 8.6 z-score
    • When combined with any of the above, a major drop of z-scores
  • Allergies – 9.2 z-score
    • With new food sensitivities – 9.9 z-score
    • When combined with any of the other, a major drop of z-scores

We have broken this down into 3 sub-groups of microbiome shifts:

SymptomReferenceStudy
Allergic Rhinitis (Hay Fever)116142
  • Bacteria Detected with z-score > 2.6: found 222 items, highest value was 8.6
  • Enzymes Detected with z-score > 2.6: found 250 items, highest value was 6.8
  • Compound Detected with z-score > 2.6: found No items

Interesting Significant Bacteria

All bacteria found significant (except 1) had too low levels. This is a common pattern found with these studies, it is not “bad bacteria bogie man bacteria” but an absence of “upstanding citizens bacteria”.

The key bacteria are very different from the other two studies in this sub-series. We do see one retail level probiotic in the list: Bifidobacterium animalis (species)

BacteriaReference MeanStudyZ-Score
Desulfovibrio (genus)27706258.6
Bacteroides stercoris (species)1418521697.8
Desulfovibrio simplex (species)213276.9
Phocaeicola sartorii (species)8072766.4
Opitutae (class)164406.1
Actinobacillus pleuropneumoniae (species)56166
Planifilum (genus)80345.9
Planifilum fimeticola (species)80345.9
Puniceicoccaceae (family)159405.9
Cerasicoccus (genus)313365.8
Actinobacillus porcinus (species)182625.4
Veillonella (genus)393519275.3
Desulfurispora thermophila (species)68355.3
Desulfurispora (genus)68355.3
Tepidanaerobacteraceae (family)55245.3
Thermoactinomycetaceae (family)81375.3
Rhodanobacteraceae (family)8382495.3
Eggerthella sinensis (species)179455.2
Lactiplantibacillus pentosus (species)120255.2
Tepidanaerobacter (genus)54245.1
Tepidanaerobacter syntrophicus (species)54245.1
Absiella (genus)728745.1
delta/epsilon subdivisions (subphylum)612231745.1
Veillonellales (order)17250116495
Bifidobacterium animalis (species)11601245

Looking at published studies we see many close matches, with most of the species cited in those studies being too low.

Note: This study and published studies suffer from the issues described in The taxonomy nightmare before Christmas…

Interesting Enzymes

All 250 enzymes found significant had too low levels.

EnzymeReference MeanStudy MeanZ-Score
chorismate hydro-lyase (3-[(1-carboxyvinyl)oxy]benzoate-forming) (4.2.1.151)16543606.8
dolichyl-diphosphooligosaccharide:protein-L-asparagine N-beta-D-oligopolysaccharidotransferase (2.4.99.18)16113186.8
S-adenosyl-L-methionine:3-[(1-carboxyvinyl)-oxy]benzoate adenosyltransferase (HCO3–hydrolysing, 6-amino-6-deoxyfutalosine-forming) (2.5.1.120)16243636.8
dehypoxanthine futalosine:S-adenosyl-L-methionine oxidoreductase (cyclizing) (1.21.98.1)16153636.7
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate:NAD+ oxidoreductase (deaminating) (1.4.1.24)15483456.6
ATP phosphohydrolase (ABC-type, tungstate-importing) (7.3.2.6)13783026.6
hydrogen:ferricytochrome-c3 oxidoreductase (1.12.2.1)13883206.6
[TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH:tRNA (5-methyluridine54-2-O)-sulfurtransferase (2.8.1.15)13593076.5
isethionate sulfite-lyase (4.4.1.38)15243186.5
ATP phosphohydrolase (ABC-type, capsular-polysaccharide-exporting) (7.6.2.12)9492396.5
6-amino-6-deoxyfutalosine deaminase (3.5.4.40)16674596.3
hydrogen-sulfide:[DsrC sulfur-carrier protein],acceptor oxidoreductase (1.8.99.5)13043236.2
futalosine ribohydrolase (3.2.2.26)12413116.1
siroheme carboxy-lyase (4.1.1.111)13405316
propanoyl-CoA:oxaloacetate C-propanoyltransferase (thioester-hydrolysing, 1-carboxyethyl-forming) (2.3.3.5)14793665.9
S-methyl-5′-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase (2.4.2.28)364615325.8
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase (succinate-forming) (4.1.3.30)14303795.6
2-dehydrotetronate isomerase (5.3.1.35)13994475.4
L-threonate:NAD+ 2-oxidoreductase (1.1.1.411)14054465.3
5-aminopentanoate:2-oxoglutarate aminotransferase (2.6.1.48)23637975.2
(S)-3-amino-2-methylpropanoate:2-oxoglutarate aminotransferase (2.6.1.22)23567965.2
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming] (4.2.1.79)12903835.1
3-deoxy-alpha-D-manno-octulopyranosonate:oxygen 8-oxidoreductase (1.1.3.48)6991965
GTP:molybdenum cofactor guanylyltransferase (2.7.7.77)1741196625
1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase (3.1.3.78)19123265

Bottom Line

We appear to have general agreement with published studies. The purpose of this series is to identify the shifts using a lab/analysis that is available to anyone world wide with the ability to identify the bacteria causing the issue with reliability and higher statistical significance than most studies.

3 thoughts on “Special Studies: Allergic Rhinitis (Hay Fever)

Leave a Reply

Your email address will not be published.