This is a common symptom for many people. This is reported often in samples, and thus being examined if it reaches our threshold for inclusion as defined in A new specialized selection of suggestions links. It does. We are not being specific about the type of allergy.

Sub-Series Study Populations:

We have 5 symptom annotations that this sub-series are examining, I tried different combination to see which resulted in a higher z-score to identify probable siblings (in a statistical sense)

• New food sensitivities – 12.1 z-score
• Medication sensitivities -8.8 z-score
  • Combined, dropped to 6.4
• Alcohol intolerance – 8.6 z-score
  • with Medication sensitivities 9.9 z-score and less bacteria
• Allergic Rhinitis (Hay Fever) – 8.6 z-score
  • When combined with any of the above, a major drop of z-scores
• Allergies – 9.2 z-score
  • With new food sensitivities – 9.9 z-score
  • When combined with any of the other, a major drop of z-scores

We have broken this down into 3 sub-groups of microbiome shifts:

• Allergies and Food Sensitivity
• Alcohol intolerance + Medication sensitivities
• Allergic Rhinitis (Hay Fever) (this study)

Symptom	Reference	Study
Allergic Rhinitis (Hay Fever)	1161	42

• Bacteria Detected with z-score > 2.6: found 222 items, highest value was 8.6
• Enzymes Detected with z-score > 2.6: found 250 items, highest value was 6.8
• Compound Detected with z-score > 2.6: found No items

Interesting Significant Bacteria

All bacteria found significant (except 1) had too low levels. This is a common pattern found with these studies, it is not “bad bacteria bogie man bacteria” but an absence of “upstanding citizens bacteria”.

The key bacteria are very different from the other two studies in this sub-series. We do see one retail level probiotic in the list: Bifidobacterium animalis (species)

Bacteria	Reference Mean	Study	Z-Score
Desulfovibrio (genus)	2770	625	8.6
Bacteroides stercoris (species)	14185	2169	7.8
Desulfovibrio simplex (species)	213	27	6.9
Phocaeicola sartorii (species)	807	276	6.4
Opitutae (class)	164	40	6.1
Actinobacillus pleuropneumoniae (species)	56	16	6
Planifilum (genus)	80	34	5.9
Planifilum fimeticola (species)	80	34	5.9
Puniceicoccaceae (family)	159	40	5.9
Cerasicoccus (genus)	313	36	5.8
Actinobacillus porcinus (species)	182	62	5.4
Veillonella (genus)	3935	1927	5.3
Desulfurispora thermophila (species)	68	35	5.3
Desulfurispora (genus)	68	35	5.3
Tepidanaerobacteraceae (family)	55	24	5.3
Thermoactinomycetaceae (family)	81	37	5.3
Rhodanobacteraceae (family)	838	249	5.3
Eggerthella sinensis (species)	179	45	5.2
Lactiplantibacillus pentosus (species)	120	25	5.2
Tepidanaerobacter (genus)	54	24	5.1
Tepidanaerobacter syntrophicus (species)	54	24	5.1
Absiella (genus)	728	74	5.1
delta/epsilon subdivisions (subphylum)	6122	3174	5.1
Veillonellales (order)	17250	11649	5
Bifidobacterium animalis (species)	1160	124	5

Looking at published studies we see many close matches, with most of the species cited in those studies being too low.

• Phocaeicola sartorii (species) <=> Phocaeicola massiliensis (NCBI:204516 )
• Bifidobacterium animalis (species) <=> Bifidobacterium (NCBI:1678 )
• Clostridium chartatabidum (species), Clostridia (class) <=> Clostridium butyricum (NCBI:1492 )
• Dialister invisus (species) <=> Dialister succinatiphilus (NCBI:487173 )

Note: This study and published studies suffer from the issues described in The taxonomy nightmare before Christmas…

Interesting Enzymes

All 250 enzymes found significant had too low levels.

Enzyme	Reference Mean	Study Mean	Z-Score
chorismate hydro-lyase (3-[(1-carboxyvinyl)oxy]benzoate-forming) (4.2.1.151)	1654	360	6.8
dolichyl-diphosphooligosaccharide:protein-L-asparagine N-beta-D-oligopolysaccharidotransferase (2.4.99.18)	1611	318	6.8
S-adenosyl-L-methionine:3-[(1-carboxyvinyl)-oxy]benzoate adenosyltransferase (HCO3–hydrolysing, 6-amino-6-deoxyfutalosine-forming) (2.5.1.120)	1624	363	6.8
dehypoxanthine futalosine:S-adenosyl-L-methionine oxidoreductase (cyclizing) (1.21.98.1)	1615	363	6.7
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate:NAD+ oxidoreductase (deaminating) (1.4.1.24)	1548	345	6.6
ATP phosphohydrolase (ABC-type, tungstate-importing) (7.3.2.6)	1378	302	6.6
hydrogen:ferricytochrome-c3 oxidoreductase (1.12.2.1)	1388	320	6.6
[TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH:tRNA (5-methyluridine54-2-O)-sulfurtransferase (2.8.1.15)	1359	307	6.5
isethionate sulfite-lyase (4.4.1.38)	1524	318	6.5
ATP phosphohydrolase (ABC-type, capsular-polysaccharide-exporting) (7.6.2.12)	949	239	6.5
6-amino-6-deoxyfutalosine deaminase (3.5.4.40)	1667	459	6.3
hydrogen-sulfide:[DsrC sulfur-carrier protein],acceptor oxidoreductase (1.8.99.5)	1304	323	6.2
futalosine ribohydrolase (3.2.2.26)	1241	311	6.1
siroheme carboxy-lyase (4.1.1.111)	1340	531	6
propanoyl-CoA:oxaloacetate C-propanoyltransferase (thioester-hydrolysing, 1-carboxyethyl-forming) (2.3.3.5)	1479	366	5.9
S-methyl-5′-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase (2.4.2.28)	3646	1532	5.8
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase (succinate-forming) (4.1.3.30)	1430	379	5.6
2-dehydrotetronate isomerase (5.3.1.35)	1399	447	5.4
L-threonate:NAD+ 2-oxidoreductase (1.1.1.411)	1405	446	5.3
5-aminopentanoate:2-oxoglutarate aminotransferase (2.6.1.48)	2363	797	5.2
(S)-3-amino-2-methylpropanoate:2-oxoglutarate aminotransferase (2.6.1.22)	2356	796	5.2
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming] (4.2.1.79)	1290	383	5.1
3-deoxy-alpha-D-manno-octulopyranosonate:oxygen 8-oxidoreductase (1.1.3.48)	699	196	5
GTP:molybdenum cofactor guanylyltransferase (2.7.7.77)	17411	9662	5
1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase (3.1.3.78)	1912	326	5

Bottom Line

We appear to have general agreement with published studies. The purpose of this series is to identify the shifts using a lab/analysis that is available to anyone world wide with the ability to identify the bacteria causing the issue with reliability and higher statistical significance than most studies.