This is reported often in samples, and thus being examined if it reaches our threshold for inclusion as defined in A new specialized selection of suggestions links.

Study Populations:

Symptom	Reference	Study
Neurocognitive:Brain Fog	1020	127

• Bacteria Detected with z-score > 2.6: found 97 items, highest value was 5.3
• Enzymes Detected with z-score > 2.6: found 309 items, highest value was 5.6
• Compound Detected with z-score > 2.6: found 571 items, highest value was 5.8

Interesting Significant Bacteria

The top item happens to have probiotics that are known to take up residency – Symbioflor-2 and Mutaflor. All of these top items are too low levels

Bacteria	Reference Mean	Study	Z-Score
Escherichia coli (species)	743	168	5.3
Lactiplantibacillus pentosus (species)	123	25	5.1
Shuttleworthia (genus)	288	95	5.1
Escherichia (genus)	5903	1500	4.5
Veillonella (genus)	4072	2522	4.4
Veillonella dispar (species)	853	127	4.4
Staphylococcus pseudolugdunensis (species)	46	20	4.2
Clostridium cellulovorans (species)	40	18	4.1

Interesting Enzymes

NADH is available as a supplement. It is reported to improve ME/CFS

Enzyme	Reference Mean	Study Mean	Z-Score
3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating) (1.14.12.19)	611	132	5.6
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate:NAD+ oxidoreductase (1.3.1.87)	598	131	5.6
propanoyl-CoA:oxaloacetate C-propanoyltransferase (thioester-hydrolysing, 1-carboxyethyl-forming) (2.3.3.5)	1514	443	5.2
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase (succinate-forming) (4.1.3.30)	1467	418	5.2
[cysteine desulfurase]-S-sulfanyl-L-cysteine:[molybdopterin-synthase sulfur-carrier protein]-Gly-Gly sulfurtransferase (2.8.1.11)	5421	2662	5.1
ATP:D-tagatose 6-phosphotransferase (2.7.1.101)	422	111	5

Interesting Compounds

All of the top compounds had lower levels

Names	Z-Score
2-Phospho-4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol (C11436)	5.8
O-Acetyl-L-homoserine (C01077)	5.4
Adenosine-GDP-cobinamide (C06510)	5.4
6-Deoxy-L-galactose (C01019)	5.2
[Enzyme]-cysteine (C15811)	5.2
Adenosyl cobyrinate a,c diamide (C06506)	5.1
Xanthosine 5′-phosphate (C00655)	5.1
dTDP-glucose (C00842)	5.1

Bottom Line

The z-scores for bacteria are lower than Long COVID which reflect the diffusion of bacteria over time. Trying to tackle at the compound or enzyme levels becomes excessively complex. Working at the bacteria level appears viable, but do not expect as many bacteria matches to appear.