A sibling is: Fungi: Clavicipitaceae / Hypocreales / Sordariomycetes

Fungi and the microbiome finally got on my radar. Apologies to some, but there is a lot of different items on the microbiome radar screen.

“Small intestinal fungal overgrowth (SIFO)… Two recent studies showed that 26 % (24/94) and 25.3 % (38/150) of a series of patients with unexplained GI symptoms had SIFO. …. but evidence for eradication is lacking.”Small intestinal fungal overgrowth [2015]

As I did with taxa years ago, I will be writing a blog on each one reviewing the literature. If there is sufficient data at the end, I may add it as a feature to Microbiome Prescription.

• CDC provides a list of known fungal diseases: Types of Fungal Diseases.
• For the current list of Fungi reviewed on this list, click Information of Different Types Of Fungi

One of my reader’s results motivated this choice. The data from a Thorne Microbiome Test. Almost 9 out of 10 people have less of it. The person also has a Crohn’s diagnosis.

Preventive for Fungi

The following are suggestions:

• Reduce and keep your living space humidity at 50% or lower (typically done by dehumidifiers). EPA recommends 30-50% [EPA]; we set our dehumidifiers for 35%.

Moisture parameters and fungal communities associated with gypsum drywall in buildings [2015]

• Use a HEPA filter appropriate to your space.
  Effectiveness of Airborne Fungi Removal by using a HEPA Air Purifier Fan in Houses [2018]
  Typically they are described as “Room Size: Up to 1500 sq.ft. maximum”. We are more aggressive and divide that by 4. For example we use 3 Austin Air HealthMate HEPA Air Purifier for our 900 sq.ft. living space.
• Check the north side of your building for mold. If found pressure wash it off and if possible, apply substances to inhibit them coming back.
• Check for mushrooms in lawns etc. If found, remove them and treat where you found them.

Remember, all fungi are not the same. Antibacterial and Antifungal Activities of Spices [2017] does not mention this fungi. Additionally, some spices are known to have Fungal Contamination of some Common Spices [2022] and Fungi and aflatoxins associated with spices in the Sultanate of Oman [2002] which included cloves (often deem an antifungal).

Basic Information

• Chaetomiaceae (Wikipedia)
• “The family contains several genera and species that have never been reported to cause human infection. ,,,  including eye and skin infections, a toe infection,  fungal peritonitis” Chaetomium-like fungi causing opportunistic infections in humans: a possible role for extremotolerance[2016] 
• Cited in Breathing can be dangerous: Opportunistic fungal pathogens and the diverse community of the small mammal lung mycobiome [2022]
• Fatal Cerebral Phaeohyphomycosis in an Immunocompetent Individual Due to Thielavia subthermophila^▿ [2011] – a member of this group.

Treatment

• From [2011], lower numbers are more effective
  • amphotericin B, 0.03 μg/ml;
  • fluconazole, 8 μg/ml;
  • itraconazole, 0.016 μg/ml;
  • voriconazole, 0.016 μg/ml;
  • posaconazole, 0.016 μg/ml;
  • isavuconazole, 0.016 μg/ml.