This is reported often in samples, and thus being examined if it reaches our threshold for inclusion as defined in A new specialized selection of suggestions links.
Study Populations:
| Symptom | Reference | Study |
| Histamine or Mast Cell Issues | 1092 | 56 |
- Bacteria Detected with z-score > 2.6: found 143 items, highest value was 8.5
- Enzymes Detected with z-score > 2.6: found 215 items, highest value was 6.1
- Compound Detected with z-score > 2.6: found ZERO items
Interesting Significant Bacteria
One of the top items happens to have probiotics that are known to take up residency – are Symbioflor-2 and Mutaflor. . All of these top items are too low levels
| Bacteria | Reference Mean | Study | Z-Score |
| Prevotella paludivivens (species) | 140 | 21 | 8.5 |
| Prevotella stercorea (species) | 6451 | 45 | 6.1 |
| Escherichia albertii (species) | 912 | 232 | 5.1 |
| Serratia (genus) | 1011 | 275 | 4.9 |
| Serratia entomophila (species) | 987 | 263 | 4.8 |
| Alishewanella (genus) | 35 | 19 | 4.7 |
| Clostridium cellulovorans (species) | 40 | 17 | 4.6 |
| Yersiniaceae (family) | 1032 | 317 | 4.6 |
| Prevotellaceae (family) | 81953 | 28733 | 4.5 |
| Prevotella copri (species) | 65645 | 13994 | 4.5 |
| Escherichia (genus) | 5617 | 1664 | 4.5 |
| Prevotella (genus) | 73889 | 22771 | 4.5 |
| Staphylococcus pseudolugdunensis (species) | 45 | 20 | 4.3 |
| Escherichia coli (species) | 712 | 234 | 4.3 |
| Schaalia naturae (species) | 211 | 37 | 4.3 |
| Atopobiaceae (family) | 132 | 39 | 4.2 |
| Rhodovibrionaceae (family) | 119 | 61 | 4.1 |
| Bulleidia (genus) | 188 | 30 | 4.1 |
Interesting Enzymes
As above, too low levels were most significant
| Enzyme | Reference Mean | Study Mean | Z-Score |
| propanoyl-CoA:oxaloacetate C-propanoyltransferase (thioester-hydrolysing, 1-carboxyethyl-forming) (2.3.3.5) | 1443 | 380 | 6.1 |
| (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase (succinate-forming) (4.1.3.30) | 1395 | 383 | 5.8 |
| S-methyl-5′-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase (2.4.2.28) | 3654 | 1517 | 5.4 |
| UDP-N-acetyl-alpha-D-glucosamine:lipopolysaccharide N-acetyl-D-glucosaminyltransferase (2.4.1.56) | 1008 | 264 | 5.2 |
| (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming] (4.2.1.79) | 1246 | 401 | 5.2 |
| n/a (3.4.23.49) | 1244 | 356 | 5.1 |
| L-carnitinyl-CoA hydro-lyase [(E)-4-(trimethylammonio)but-2-enoyl-CoA-forming] (4.2.1.149) | 1380 | 367 | 5 |
| acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (6,7 cis-dehydrogenating) (1.14.19.3) | 1013 | 302 | 5 |
Interesting Compounds
Nothing was found!!!! In one sense this was a surprise, in another sense, it hints that the results found significant are not random.
Bottom Line
Histamine or Mast Cell Issues appears to a condition of deficiency. Common internet thinking is that it is a condition of a surplus of histamine producing bacteria. It is more likely that the normal histamine consumers are being starved of enzymes that are needed to stop the accumulation of histamine.
“It is more likely that the normal histamine consumers are being starved of enzymes that are needed to stop the accumulation of histamine.” Starved by overgrowths of competitive bacteria? Or starved by another reason?
Is there some way we can get these histamine consumers their enzymes, without feeding pathogenic bacteria?
The short answer is that you need to understand the processes involved with all of it’s complexities.
See https://www.kegg.jp/entry/C00388
Especially Histidine metabolism – Reference pathway https://www.kegg.jp/pathway/map00340+C00388
Recommended reading: https://pediaa.com/what-is-the-difference-between-histidine-and-histamine/
I believe histidine, the food that produces histamine is what you want to target,
Hey, sorry, I’m not sure how to interpret the add / decrease columns, should I be removing the decrease column from my diet, or does the decrease column decrease the problem, many thanks in advance
Increase and decrease indicates the action to be taken