A mother with Premenstrual Dysphoric Disorder

Back Story For Mother

“Lots of high % potential health stuff. In real time, mother’s very hormone sensitive . Gets like a Premenstrual dysphoric disorder (PMDD) state , feels depressed. Struggles with anxiety and depression in general . Notice she’s been getting allergies. During the birth of 2nd child two years ago; mother had to get vancomycin because she was strep B positive. When the family get sick, the mother gets the sickest of the 4 of us unfortunately. Mother caught COVID in Sep 2022. Mother’s cycles in 2021 started to be heavy where before that never happened. As a kid, mother was on Accutane a lot. When mothers results through biomesight I also got a message that said unusually small file size or something along those lines.”

Foreword – and Reminder

I am not a licensed medical professional and there are strict laws where I live about “appearing to practice medicine”.  I am safe when it is “academic models” and I keep to the language of science, especially statistics. I am not safe when the explanations have possible overtones of advising a patient instead of presenting data to be evaluated by a medical professional before implementing.

I cannot tell people what they should take or not take. I can inform people items that appears to have better odds of improving their microbiome as a results on numeric calculations. I am a trained experienced statistician with appropriate degrees and professional memberships. All suggestions should be reviewed by your medical professional before starting.

Mother Overview

  • Jason Hawrelak Recommendations – 99.7%ile (better than most), High Roseburia, Blautia. The others are low

Checking on the two studies that I could find Premenstrual dysphoric disorder

If you can locate any other studies, please send to me.

Tax NameShiftPercentile
Bacteroidia (NCBI:200643 )Low4%ile
Anaerotaenia (NCBI:1843206 )Highnot reported by lab
Bifidobacterium (NCBI:1678 )High80%ile
Blautia (NCBI:572511 )High98%ile
Butyricicoccus (NCBI:580596 )Lownot reported by lab
Collinsella (NCBI:102106 )High0%ile
Extibacter (NCBI:1918452 )Lownot reported by lab
Megasphaera (NCBI:906 )Low92%ile
Parabacteroides (NCBI:375288 )Low67%ile
Bacteroidetes (NCBI:976 )Low4%ile

This suggests that we have a general match with the literature and should include in our consensus, a hand picked set of suggestions.

There is an abundance of bacteria which are there, but at low levels.

We have an impressive list of bacteria deemed unhealthy. Note that counts are often small (agreeing with the abundance of bacteria at low levels seen above).

NameRankPercentileCountCommentMore Info
Actinomycesgenus87230PathogenCitation
Anaerotruncus colihominisspecies782380Not Healthy PredictorCitation
Bacteroides fragilisspecies745659PathogenCitation
Blautia productaspecies751440Not Healthy PredictorCitation
Clostridiumgenus7221469PathogenCitation
Collinsellagenus010High COVID RiskCitation
Corynebacteriumgenus891520PathogenCitation
Doreagenus9723040Increased COVID riskCitation
Eggerthella lentaspecies993469Not Healthy PredictorCitation
Finegoldia magnaspecies91830Infectious bacteriaCitation
Granulicatella adiacensspecies8480Not Healthy PredictorCitation
Leptospiragenus92160PathogenCitation
Peptoniphilus hareispecies6750Infectious bacteriaCitation
Peptoniphilus lacrimalisspecies78170Infectious bacteriaCitation
Peptostreptococcusgenus83170PathogenCitation
Peptostreptococcus stomatisspecies88150Not Healthy PredictorCitation
Prevotella timonensisspecies951890Infectious bacteriaCitation
Ruminococcus gnavusspecies9962200Not Healthy PredictorCitation
Staphylococcus haemolyticusspecies7240PathogenCitation
Streptococcus vestibularisspecies65370Not Healthy PredictorCitation
Veillonella atypicaspecies94859Not Healthy PredictorCitation

Potential Medical Conditions Detected had at 99%ile, Schizophrenia, which suggests some overlap with PMDD.

Going Forward

I added a new choice to the site that gets canned suggestions for Bacteria Deemed Unhealthy above because of the large number of bacteria flagged in this sample.

The new option

The suggestions for this person with this new option.

33 bacteria was selected.

Building the Consensus

I am building from:

  • Hand Picked (see above focused on PMDD) (4 picked)
  • Unhealthy Suppression – just added (33 picked)
  • Outside Range from Nirvana/CosmosId (5 picked)
  • Outside Lab Range (+/- 1.96SD) (6 picked)
  • Outside Box-Plot-Whiskers (60 picked)
  • Outside Kaltoft-Moldrup (95 picked)

The top items to suggested to take are shown below (meat and B-vitamins are concentric):

The top items to suggested to avoid are shown below

Mother_ConsensusDownload

Probiotics

We have a challenge here, take lactobacillus rhamnosus gg (probiotics) by itself is a -409, but in combination with propionibacterium freudenreichii it is 190-263. This suggests that bacteria as a supplement ( Nutricology/Securil ) or lots of real Emmental cheese (which uses it).

Similarly lactobacillus salivarius (probiotics) is a negative -275 but Lactobacillus salivarius UCC118 is a positive 285. I would avoid it, instead of playing probiotic roulette.

The next one on the list as a reasonable candidate is lactobacillus fermentum (probiotics), then mutaflor escherichia coli nissle 1917 (probiotics).

Going over to KEGG suggestions, the top choices (not in Prescript Assist which is a negative) are (in order)

Which points to microbiome labs/ megasporebiotic OR organic 3 / primal soil (see probiotic page for other choices)

My suggestion for rotation would be: