This is a doubly naive test of Odd Ratios to predict symptoms from Microbiome data. For background see New Standards for Microbiome Analysis? This is intended to be a rough demonstration of concept.

• I arbitrarily picked resulting odds of 1.0 as a division line (i.e. no increased odds). This is a definite bias threshold
• The percentage of samples for those with declared symptoms and those without is shown below
• No adjustment for those that failed to declare any symptoms which will inflate the Has Not %

Noticeable cases

• Mouth Sores: Those with had 17% over 1.0 while those without had just 1.7%
• Non-alcoholic Fatty Liver Disease  with 48% over 1.0 while those without had just 4%
• Sleep Apnea Diagnosis: 50% vs 10%
• Live in house with person with probable microbiome dysfunction: 53% vs 8%
• Determine age from a microbiome sample seem very possible (with gender being less predictable)
• Only 2 out of 297 symptoms are possible failures for predictions.
  • Neurocognitive: Difficulty expressing thoughts
  • Sleep: Daytime drowsiness

Symptomname	Has %	Has Not %
Age: 20-30	93.89	80.92
Age: 30-40	70.90	68.59
Age: 40-50	79.29	67.46
Age: 50-60	73.83	51.59
Age: 60-70	75.00	39.40
Asymptomatic: Live in house with person with probable microbiome dysfunction	52.94	7.96
Autism: High Functioning	74.29	28.41
Autonomic Manifestations: bladder dysfunction	90.91	63.60
Autonomic Manifestations: cardiac arrhythmias	91.30	45.00
Autonomic Manifestations: Cortisol disorders or irregularity	86.36	50.22
Autonomic Manifestations: exertional dyspnea	70.97	41.79
Autonomic Manifestations: irritable bowel syndrome	74.24	68.54
Autonomic Manifestations: light-headedness	85.19	70.37
Autonomic Manifestations: nausea	85.45	56.96
Autonomic Manifestations: Orthostatic intolerance	76.43	58.32
Autonomic Manifestations: palpitations	72.78	60.28
Autonomic Manifestations: Postural orthostatic tachycardia syndrome (POTS)	71.08	59.78
Autonomic Manifestations: urinary frequency dysfunction	84.21	61.23
Autonomic: Blurred or tunnel vision after standing	60.66	21.84
Autonomic: Dizziness or fainting	67.57	38.72
Autonomic: Heart rate increase after standing	80.79	73.37
Autonomic: Inability to tolerate an upright position	76.77	41.80
Autonomic: Irregular heartbeats	57.84	26.09
Autonomic: Nausea	76.60	54.04
Autonomic: Ocassional Tachycardia (Rapid heart beat)	73.81	60.54
Autonomic: Shortness of breath	77.78	62.92
Blood Type: A Positive	75.00	50.37
Blood Type: B Positive	81.08	44.46
Blood Type: O Positive	67.37	39.86
Comorbid-Mouth: Bruxism – Jaw cleanching / Teeth grinding	74.86	66.25
Comorbid-Mouth: Dry Mouth	69.91	44.90
Comorbid-Mouth: Gingivits / Gum Disease	90.54	57.62
Comorbid-Mouth: Mouth Sores	17.50	1.72
Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome	59.49	25.47
Comorbid: Carbohydrate intolerance	54.39	17.47
Comorbid: Constipation and Diarrohea (not explosions)	61.94	45.39
Comorbid: Constipation and Explosions (not diarrohea)	58.18	17.16
Comorbid: Fibromyalgia	74.42	42.48
Comorbid: High Anxiety	72.81	64.06
Comorbid: Histamine or Mast Cell issues	68.44	66.44
Comorbid: Hypothyroidism	83.19	71.06
Comorbid: Inflammatory bowel disease	37.50	8.51
Comorbid: Methylation issues (MTHFR)	86.55	70.34
Comorbid: Migraine	66.67	42.64
Comorbid: Mold Sensitivity / Exposure	58.21	32.02
Comorbid: Mood Swings	84.78	78.39
Comorbid: Multiple Chemical Sensitivity	71.43	49.60
Comorbid: Panic Attacks	72.00	36.91
Comorbid: Raynaud’s syndrome (Skin discoloration)	53.23	20.21
Comorbid: Restless Leg	84.95	69.91
Comorbid: Salicylate sensitive	78.26	30.66
Comorbid: Sleep Apnea Diagnosis	49.15	10.68
Comorbid: Small intestinal bacterial overgrowth (SIBO)	61.40	42.31
Comorbid: Snoring (NOT Sleep Apnea	76.19	48.97
Comorbid: Sugars cause sleep or cognitive issues	76.56	37.62
Condition: Acne	65.49	39.41
Condition: Asthma	77.14	48.12
Condition: Generalized anxiety disorder	48.65	15.81
Condition: ME/CFS with IBS	75.34	67.31
Condition: ME/CFS without IBS	80.82	68.52
Condition: Non-alcoholic Fatty Liver Disease	47.83	3.75
Condition: Non-Celiac Gluten Sensitivity	77.30	66.87
Condition: Post-Traumatic Stress Disorder	64.29	32.76
Condition: Psoriasis	93.33	62.81
DePaul University Fatigue Questionnaire : Abdomen pain	86.24	76.52
DePaul University Fatigue Questionnaire : Abnormal sensitivity to light	73.68	54.05
DePaul University Fatigue Questionnaire : Absent-mindedness	84.46	70.80
DePaul University Fatigue Questionnaire : Allergies	70.55	59.30
DePaul University Fatigue Questionnaire : Anxiety/tension	75.00	66.19
DePaul University Fatigue Questionnaire : Blurred Vision	46.15	21.39
DePaul University Fatigue Questionnaire : Chemical sensitivity	70.65	42.72
DePaul University Fatigue Questionnaire : Chest pain	60.78	20.40
DePaul University Fatigue Questionnaire : Chilled or shivery	60.98	25.61
DePaul University Fatigue Questionnaire : Concern with driving	87.50	63.74
DePaul University Fatigue Questionnaire : Confusion/disorientation	94.44	65.47
DePaul University Fatigue Questionnaire : Depression	69.92	54.12
DePaul University Fatigue Questionnaire : Difficulty comprehending Information	79.04	70.56
DePaul University Fatigue Questionnaire : Difficulty falling asleep	83.23	69.44
DePaul University Fatigue Questionnaire : Difficulty finding the right word	76.72	70.66
DePaul University Fatigue Questionnaire : Difficulty following things	75.00	63.12
DePaul University Fatigue Questionnaire : Difficulty reasoning things out	75.00	59.68
DePaul University Fatigue Questionnaire : Difficulty recalling information	74.88	68.58
DePaul University Fatigue Questionnaire : Difficulty retaining information	74.18	67.67
DePaul University Fatigue Questionnaire : Difficulty staying asleep	71.11	63.18
DePaul University Fatigue Questionnaire : Dizziness	91.67	72.70
DePaul University Fatigue Questionnaire : Does physical activity make you feel better	92.06	83.64
DePaul University Fatigue Questionnaire : Does physical activity make you feel worse	72.44	66.05
DePaul University Fatigue Questionnaire : Easily irritated	73.02	68.50
DePaul University Fatigue Questionnaire : Eye pain	53.33	15.04
DePaul University Fatigue Questionnaire : Fatigue	70.03	66.36
DePaul University Fatigue Questionnaire : Feel unsteady on feet	93.33	61.10
DePaul University Fatigue Questionnaire : Feeling like you have a temperature	76.00	31.74
DePaul University Fatigue Questionnaire : Fever & Chills	65.71	31.26
DePaul University Fatigue Questionnaire : Forgetting what you are trying to say	82.02	75.04
DePaul University Fatigue Questionnaire : Frequently get words or numbers in the wrong order	61.84	31.45
DePaul University Fatigue Questionnaire : Frequently loose train of thought	86.16	79.97
DePaul University Fatigue Questionnaire : Headaches	65.52	48.24
DePaul University Fatigue Questionnaire : Hot or Cold spells	81.55	60.31
DePaul University Fatigue Questionnaire : Impaired Memory & concentration	76.14	74.01
DePaul University Fatigue Questionnaire : Mood swings	76.19	54.35
DePaul University Fatigue Questionnaire : Muscle Pain (i.e., sensations of pain or aching in your muscles. This does not include weakness or pain in other areas such as joints)	62.99	50.53
DePaul University Fatigue Questionnaire : Muscle weakness	72.86	54.16
DePaul University Fatigue Questionnaire : Nausea	73.81	49.45
DePaul University Fatigue Questionnaire : Need to have to focus on one thing at a time	83.16	70.72
DePaul University Fatigue Questionnaire : Need to nap during each day	85.44	72.33
DePaul University Fatigue Questionnaire : New trouble with math	76.06	43.07
DePaul University Fatigue Questionnaire : Night sweats	89.33	62.03
DePaul University Fatigue Questionnaire : Pain in Multiple Joints without Swelling or Redness	63.33	40.29
DePaul University Fatigue Questionnaire : Poor Appetite	88.10	44.71
DePaul University Fatigue Questionnaire : Post-exertional malaise, feeling worse after doing activities that require either physical or mental exertion	75.09	68.46
DePaul University Fatigue Questionnaire : Racing heart	60.87	46.13
DePaul University Fatigue Questionnaire : Rash	63.08	29.39
DePaul University Fatigue Questionnaire : Ringing in the Ears	71.17	61.15
DePaul University Fatigue Questionnaire : Sensitivity to Alcohol	73.28	58.50
DePaul University Fatigue Questionnaire : Shortness of breath	70.19	41.20
DePaul University Fatigue Questionnaire : Slow to react	92.55	72.04
DePaul University Fatigue Questionnaire : Slowness of thought	75.88	63.98
DePaul University Fatigue Questionnaire : Sore Throat	83.95	60.48
DePaul University Fatigue Questionnaire : Temperature lower than normal	72.62	39.48
DePaul University Fatigue Questionnaire : Tense muscles	75.00	50.95
DePaul University Fatigue Questionnaire : Tingling feeling	53.85	25.61
DePaul University Fatigue Questionnaire : Trouble expressing thoughts	71.22	53.85
DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired	71.73	70.38
DePaul University Fatigue Questionnaire : Upset stomach	60.75	27.32
DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM)	90.23	76.05
DePaul University Fatigue Questionnaire : Weight change	64.00	32.97
Gender: Female	82.69	73.88
Gender: Male	74.20	69.66
General: Anhedonia (inability to feel pleasure)	86.32	55.28
General: Depression	70.88	55.53
General: Fatigue	74.29	71.67
General: Headaches	52.25	46.13
General: Heavy feeling in arms and legs	68.49	44.97
General: Myalgia (pain)	44.93	32.60
General: Sinus issues with headaches	85.90	74.92
Immune Manifestations: Abdominal Pain	62.94	52.36
Immune Manifestations: Alcohol Intolerant	76.97	64.47
Immune Manifestations: Bloating	66.92	66.53
Immune Manifestations: Chronic Flatus / Flatulence / gas	74.25	66.73
Immune Manifestations: Constipation	70.04	66.56
Immune Manifestations: Diarrhea	50.00	28.82
Immune Manifestations: general malaise	71.02	69.42
Immune Manifestations: Hair loss	76.67	71.79
Immune Manifestations: Inflammation (General)	66.28	56.08
Immune Manifestations: Inflammation of skin, eyes or joints	68.57	51.72
Immune Manifestations: medication sensitivities.	79.49	54.83
Immune Manifestations: Mucus in the stool	43.40	15.96
Immune Manifestations: new food sensitivities	74.52	57.92
Immune Manifestations: recurrent flu-like symptoms	72.12	56.40
Immune Manifestations: tender lymph nodes	82.95	53.88
Immune Manifestations: Thick blood / Hypercoagulation	65.57	32.43
Immune: Chronic Sinusitis	80.70	63.26
Immune: Flu-like symptoms	94.93	85.48
Immune: Recurrent Sore throat	73.85	62.61
Immune: Sensitivity to smell/food/medication/chemicals	69.23	55.43
Immune: Tender / sore lymph nodes	82.02	57.33
Immune: Viral infections with prolonged recovery periods	83.52	66.38
Infection: Lyme	83.61	42.25
Infection: Parasite – Other	58.14	19.97
Joint: Stiffness and swelling	73.26	41.44
Joint: Tenderness	76.14	44.00
Neurocognitive: Absent-mindedness or forgetfulness	69.09	67.75
Neurocognitive: Aphantasia ( inability to visualize mental images)	91.94	60.69
Neurocognitive: Brain Fog	77.18	75.16
Neurocognitive: Can only focus on one thing at a time	72.31	70.26
Neurocognitive: Difficulty expressing thoughts	70.19	70.30
Neurocognitive: Difficulty paying attention for a long period of time	72.00	70.40
Neurocognitive: Difficulty understanding things	82.12	74.98
Neurocognitive: Feeling disoriented	68.42	44.29
Neurocognitive: Problems remembering things	70.70	68.50
Neurocognitive: Slowness of thought	75.36	68.44
Neurocognitive: Unable to focus vision and/or attention	70.93	51.42
Neuroendocrine Manifestations: abnormal appetite	60.00	19.81
Neuroendocrine Manifestations: Air Hunger	65.98	39.13
Neuroendocrine Manifestations: cold extremities	71.16	65.39
Neuroendocrine Manifestations: Dry Eye (Sicca or Sjogren Syndrome)	70.90	54.43
Neuroendocrine Manifestations: Excessive adrenaline	77.06	53.32
Neuroendocrine Manifestations: intolerance of extremes of heat and cold	66.24	59.28
Neuroendocrine Manifestations: Laboured breathing	76.60	23.34
Neuroendocrine Manifestations: loss of adaptability	89.74	67.64
Neuroendocrine Manifestations: marked weight change	76.83	34.14
Neuroendocrine Manifestations: Muscle weakness	77.27	54.99
Neuroendocrine Manifestations: Painful menstrual periods	94.12	69.75
Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin)	63.01	23.15
Neuroendocrine Manifestations: Poor gut motility	72.25	62.39
Neuroendocrine Manifestations: Rapid muscular fatiguability	84.29	73.44
Neuroendocrine Manifestations: recurrent feelings of feverishness	67.57	21.10
Neuroendocrine Manifestations: subnormal body temperature	84.15	52.21
Neuroendocrine Manifestations: sweating episodes	80.43	57.88
Neuroendocrine Manifestations: worsening of symptoms with stress.	67.31	64.50
Neuroendocrine: Alcohol intolerance	75.74	66.51
Neuroendocrine: Chills or shivers	65.31	27.13
Neuroendocrine: Cold limbs (e.g. arms, legs hands)	76.92	66.09
Neuroendocrine: Feeling hot or cold for no reason	72.48	60.73
Neuroendocrine: Feeling like you have a high temperature	57.58	22.85
Neuroendocrine: Feeling like you have a low temperature	78.13	52.31
Neuroendocrine: Lack of appetite	88.14	49.39
Neuroendocrine: Lost or gained weight without trying	55.47	31.01
Neuroendocrine: Temperature fluctuations throughout the day	57.75	14.41
Neurological-Audio: hypersensitivity to noise	78.63	72.69
Neurological-Audio: Tinnitus (ringing in ear)	72.99	64.51
Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep)	33.33	9.33
Neurological-Sleep: Inability for deep (delta) sleep	83.09	63.61
Neurological-Sleep: Insomnia	75.00	65.60
Neurological-Sleep: Night Sweats	84.38	67.94
Neurological-Sleep: Prolonged Sleep	84.06	45.50
Neurological-Sleep: Sleep Apnea	78.67	28.87
Neurological-Sleep: Vivid Dreams/Nightmares	62.50	27.44
Neurological-Vision: Blurred Vision	47.37	24.65
Neurological-Vision: inability to focus eye/vision	54.02	32.06
Neurological-Vision: photophobia (Light Sensitivity)	75.91	59.42
Neurological: Cognitive/Sensory Overload	70.28	68.06
Neurological: Confusion	38.67	12.56
Neurological: Difficulty processing information (Understanding)	73.37	61.92
Neurological: Difficulty reading	81.38	66.94
Neurological: Disorientation	55.22	15.73
Neurological: Dysautonomia	62.73	48.21
Neurological: emotional overload	63.13	50.84
Neurological: Executive Decision Making (Difficulty making)	66.25	48.05
Neurological: fasciculations	76.56	50.32
Neurological: High degree of Empathy before onset	80.20	47.61
Neurological: Impairment of concentration	64.84	54.93
Neurological: Joint hypermobility	79.21	64.85
Neurological: Myoclonic jerks or seizures	88.14	42.00
Neurological: Neuropathy	79.00	52.27
Neurological: Seasonal Affective Disorder (SAD)	52.00	23.11
Neurological: Short-term memory issues	76.42	67.34
Neurological: Slowed speech	66.67	28.63
Neurological: Word-finding problems	71.79	70.78
Official Diagnosis: Allergic Rhinitis (Hay Fever)	77.39	62.02
Official Diagnosis: Attention deficit hyperactivity disorder (ADHD)	80.90	53.50
Official Diagnosis: Autism	80.00	32.49
Official Diagnosis: Autoimmune Disease	69.32	39.77
Official Diagnosis: Chronic Fatigue Syndrome (CFS/ME)	78.84	70.99
Official Diagnosis: COVID19 (Fully Recovered)	58.90	35.62
Official Diagnosis: COVID19 (Long Hauler)	68.00	58.50
Official Diagnosis: Depression	66.67	34.73
Official Diagnosis: Fibromyalgia	62.50	24.63
Official Diagnosis: Gastroesophageal reflux disease (GERD)	70.67	32.19
Official Diagnosis: Hypercholesterolemia (High Cholesterol)	66.67	19.13
Official Diagnosis: Irritable Bowel Syndrome	76.34	62.35
Official Diagnosis: Mast Cell Dysfunction	39.36	14.21
Onset: 2000-2010	84.72	57.96
Onset: 2010-2020	75.89	57.23
Onset: Gradual	75.53	57.86
Onset: less than 02 years since onset	77.05	37.15
Onset: less than 04 years since onset	80.00	53.63
Onset: less than 08 years since onset	73.33	32.27
Onset: less than 16 years since onset	85.19	56.03
Onset: less than 32 years since onset	88.41	62.45
Onset: Sudden	87.95	62.02
Other: Sensitivity to mold	61.16	35.90
Other: Sensitivity to vibrations	73.13	46.49
Pain: Aching of the eyes or behind the eyes	70.21	39.83
Pain: Chest pain	46.67	22.48
Pain: Eye pain	58.46	24.83
Pain: Joint pain	67.46	53.09
Pain: Myofascial pain	59.32	25.27
Pain: Pain or aching in muscles	68.87	53.55
Pain: Peripheral neuropathy	46.77	15.02
Pain: Sensitivity to pain	56.98	35.84
Physical: Amalgam fillings	68.89	39.36
Physical: Appendix removed	78.13	34.68
Physical: Breastfed	85.54	74.91
Physical: Eastern European	90.12	75.02
Physical: Good Air Quality	65.22	30.88
Physical: Long term (chronic) stress	76.69	62.75
Physical: Northern European	78.98	63.54
Physical: Organic Diet	81.36	60.94
Physical: Pets	76.85	61.49
Physical: Steps Per Day < 2000	87.96	70.62
Physical: Steps Per Day 2000-4000	95.24	72.36
Physical: Steps Per Day 4000-8000	62.50	43.59
Physical: Steps Per Day 8000-16000	81.82	32.44
Physical: Tonsils removed	59.18	34.94
Physical: Work-Sitting	85.29	77.12
Post-exertional malaise: Difficulty reading after mild physical or mental activity	76.92	64.66
Post-exertional malaise: General	73.12	69.93
Post-exertional malaise: Inappropriate loss of physical and mental stamina,	73.31	68.56
Post-exertional malaise: Mentally tired after the slightest effort	83.54	75.52
Post-exertional malaise: Muscle fatigue after mild physical activity	75.64	69.84
Post-exertional malaise: Next-day soreness after everyday activities	77.71	63.47
Post-exertional malaise: Physically drained or sick after mild activity	76.59	68.30
Post-exertional malaise: Physically tired after minimum exercise	73.08	68.42
Post-exertional malaise: Post-exertional malaise	76.42	71.33
Post-exertional malaise: Rapid cognitive fatigability,	83.94	77.58
Post-exertional malaise: Rapid muscular fatigability,	71.33	63.00
Post-exertional malaise: Worsening of symptoms after mild mental activity	72.73	60.37
Post-exertional malaise: Worsening of symptoms after mild physical activity	69.50	62.96
Sleep: Daytime drowsiness	66.42	66.74
Sleep: Need to nap daily	80.00	74.85
Sleep: Problems falling asleep	73.74	68.28
Sleep: Problems staying asleep	66.92	64.75
Sleep: Unrefreshed sleep	64.00	63.37
Sleep: Waking up early in the morning (e.g. 3 AM)	71.20	62.79
Virus: Epstein-Barr virus	74.40	54.03
Virus: Human Herpesvirus 6 positive (HHV6)	77.97	48.97