Condition Templates

There is growing acceptance that specific conditions have a pattern of microbiome shifts. There is likely a complex two way interaction between conditions and the microbiome. We do know from both studies and personal experience, that symptoms associated with a condition decreases as the microbiome shift closer to normal or typical.

The templates are a summary of abnormal shifts reported on the US National Library of Medicine. There are often technical issues with these studies, a few simple examples.

  • Patients are often from the same medical practise, so they have been subject to interventions — the results may reflect the interventions and not the actual conditions. If 50% of the patients are gluten free, the results may reflect being gluten free and not the condition.
  • Region effects in diet or even patient traditional lab results can impact the microbiome. A study of patients in Bangor, Maine vs Miami, Florida will likely show significant different levels of Vitamin D. We know that Vitamin D impacts the microbiome (see this listing on the site).

The condition templates is an aggregation of everything reported in the literature. There is no review or evaluation of the study — which is intentional, because there are often very few published studies. For some bacteria you will see ‘High or Low’ which means often that one study reported high levels and a different one reported low. The complexity of microbiome interactions means there is no single right answer.

What has reports to date?

This list has grown a lot over the last year and will likely keep growing.

  • Acne
  • ADHD
  • Allergies
  • Alzheimer’s disease
  • Amyotrophic lateral sclerosis (ALS) Motor Neuron
  • Ankylosing spondylitis
  • Asthma
  • Autism
  • Autoimmune Disease
  • Barrett esophagus cancer
  • Brain Trauma
  • Celiac Disease
  • Chronic Fatigue Syndrome
  • Chronic Kidney Disease
  • Colorectal Cancer
  • Crohn’s Disease
  • Depression
  • Epilepsy
  • Fibromyalgia
  • Functional constipation / chronic idiopathic constipation
  • Gastro-esophageal reflux disease (Gerd)
  • Generalized anxiety disorder
  • Gout
  • Graves’ disease
  • Hashimoto’s thyroiditis
  • High Blood Pressure
  • Histamine Issues
  • Histamine Issues From Ubiome
  • IgA nephropathy (IgAN)
  • Inflammatory Bowel Disease
  • Iron Consumers
  • Irritable Bowel Syndrome
  • Juvenile idiopathic arthritis
  • Liver Cirrhosis
  • Metabolic Syndrome
  • Mood Disorders
  • Multiple Sclerosis
  • Non-alcoholic Fatty Liver Disease
  • Non-Celiac Gluten Sensitivity
  • Osteoarthritis
  • Parkinson’s Disease
  • Psoriasis
  • Rheumatoid arthritis
  • rheumatoid arthritis (RA) and Spondyloarthritis (SpA)
  • Schizophrenia
  • Sclerosis
  • Sjögren syndrome
  • Small Intestinal Bacterial Overgrowth (SIBO)
  • Stress / post-traumatic stress disorder
  • Systemic Lupus Erythematosus
  • Type 1 Diabetes
  • Type 2 Diabetes
  • Ulcerative colitis

A “Match” does not mean the condition

If you have the condition, then this can be helpful for getting a sense of where you are. Having less matches usually implies less symptoms.

The numbers below are for myself:

The first two columns are from a period of remission, the third number from a flare, the last number from after several weeks of aggressive treatment.

It says that the flare was likely caused by an overgrowth (HIGH jumped by 42%). It does not pinpoint one bacteria — in reality, the issue is a consortium of different bacteria reinforcing each other.

Shifts in the following 4 genus are seen across 20 of these conditions. It is unlikely that you have all 20 conditions.

  • Bacteroides
  • Prevotella
  • Lactobacillus
  • Bifidobacterium