I just got an email asking for which bacteria are involved with Mast Cells and Histamine issues. This post is just presenting the tables derived from the methodology described in this technical post: Odds Ratios and the Microbiome. We do not have sufficient data for Mast Cell Activation Syndrome (MCAS)

Here are some odds ratios using BiomeSight data. Odds Low means when the reading is below the Median and Odds High above the Median (of those with this symptom). We use the symptom median to get balanced (same approximate size) categories. Using an average results in poorer results.

A 1.2 in Odds Low, means that having less then typical/median increases your odds, i.e. you want to increase the amount.

Official Diagnosis: Mast Cell Dysfunction

At first look for probiotics (i.e. Odds Low over 1, too low), we see:

• Akkermansia muciniphila
• Lactococcus

Tax_Name	tax_Rank	Odds Low	Odd High
Sharpea	genus	0.73	1.67
Sharpea azabuensis	species	0.73	1.66
Haemophilus	genus	1.58	0.69
Haemophilus parainfluenzae	species	1.57	0.70
Pasteurellales	order	1.54	0.74
Pasteurellaceae	family	1.54	0.74
Veillonella atypica	species	1.53	0.63
[Ruminococcus] torques	species	0.75	1.49
Erysipelothrix muris	species	0.76	1.49
Amedibacillus dolichus	species	0.76	1.48
Amedibacillus	genus	0.76	1.48
Lactococcus	genus	1.48	0.70
Erysipelothrix	genus	0.77	1.48
Syntrophobacterales	order	0.77	1.45
Syntrophobacteria	class	0.77	1.45
Holdemania	genus	0.77	1.43
Turicibacter	genus	1.42	0.77
Turicibacteraceae	family	1.42	0.77
Alkaliphilus crotonatoxidans	species	1.41	0.77
Chloroflexota	phylum	1.41	0.75
Slackia	genus	1.40	0.77
Serratia entomophila	species	0.78	1.40
Yersiniaceae	family	0.79	1.38
Limnobacter	genus	0.79	1.38
Limnobacter litoralis	species	0.79	1.38
Holdemanella	genus	1.37	0.77
Holdemanella biformis	species	1.37	0.77
Thermodesulfobacteriota	phylum	1.36	0.79
Ruminiclostridium cellobioparum subsp. termitidis	subspecies	1.36	0.79
Ruminiclostridium cellobioparum	species	1.36	0.79
Alkaliphilus	genus	1.36	0.78
Sutterella sanguinus	species	1.35	0.78
Akkermansiaceae	family	1.35	0.78
Ruminococcus albus	species	1.35	0.79
Akkermansia	genus	1.35	0.78
Akkermansia muciniphila	species	1.35	0.78
Anaerolineae	class	1.34	0.75
Desulfuromonadia	class	1.34	0.78
Desulfuromonadales	order	1.34	0.78
Parabacteroides merdae	species	1.33	0.80
PVC group	clade	1.33	0.80
Rhodanobacteraceae	family	1.33	0.79
Verrucomicrobiota	phylum	1.33	0.80
Sphingobacterium	genus	1.31	0.81
Oribacterium	genus	1.30	0.81
Veillonella dispar	species	1.30	0.77
Ruminiclostridium	genus	1.30	0.80
Oribacterium sinus	species	1.29	0.82
Odoribacter	genus	1.28	0.82
Verrucomicrobiaceae	family	1.28	0.82
Verrucomicrobiia	class	1.28	0.82
Desulfuromonadaceae	family	1.28	0.81
Verrucomicrobiales	order	1.27	0.82
Streptococcaceae	family	1.27	0.82
Clostridium taeniosporum	species	1.26	0.79
Flavobacteriia	class	1.26	0.82
Flavobacteriaceae	family	1.26	0.82
Flavobacteriales	order	1.26	0.82
Sutterella wadsworthensis	species	1.26	0.81
delta/epsilon subdivisions	clade	1.25	0.83
Lysobacterales	order	1.25	0.83
Heliobacteriaceae	family	1.25	0.77
Streptococcus thermophilus	species	1.24	0.82
Deltaproteobacteria	class	1.24	0.83
Gillisia	genus	1.24	0.83
Actinomycetota	phylum	1.24	0.84
Actinobacillus	genus	1.24	0.84
Sutterella stercoricanis	species	1.24	0.83
Gillisia limnaea	species	1.23	0.84
Phocaeicola plebeius	species	1.23	0.75
Bacteroides stercoris	species	1.22	0.85
Streptococcus	genus	1.22	0.84
Alcaligenaceae	family	1.21	0.85
Desulfovibrionia	class	1.21	0.85
Desulfovibrionales	order	1.21	0.85
Sutterella	genus	1.21	0.85
Sutterellaceae	family	1.21	0.85
Mitsuokella	genus	1.21	0.77
Actinomycetales	order	1.21	0.83
Betaproteobacteria	class	1.20	0.85
Rhodothermaceae	family	1.20	0.84
Anaerobranca zavarzinii	species	1.20	0.85
Anaerobranca	genus	1.20	0.85
Proteinivoraceae	family	1.20	0.85

Comorbid: Histamine or Mast Cell issues

This is a little more fuzzy for the criteria. With too low levels being very common but not as common as seen with Odds Ratios for Neurological-Audio: hypersensitivity to noise

At first look for probiotics (i.e. Odds Low over 1, too low), we see:

• Bifidobacterium adolescentis
• Lactococcus
• Bifidobacterium longum
• Ligilactobacillus, i.e. Ligilactobacillus salivarius (L. Salivarius)

Tax_Name	tax_Rank	Odds Low	Odd High
Bifidobacterium angulatum	species	1.96	0.58
Sphingobium	genus	1.73	0.63
Vagococcus teuberi	species	1.69	0.70
Catenibacterium mitsuokai	species	1.65	0.52
Polyangia	subclass	1.58	0.65
Segatella paludivivens	species	1.56	0.73
Hoylesella loescheii	species	1.54	0.64
Filifactor villosus	species	0.78	1.54
Myxococcota	phylum	1.54	0.59
Myxococcales	order	1.54	0.59
Myxococcia	class	1.54	0.59
Aggregatibacter	genus	1.48	0.76
Luteolibacter	genus	0.77	1.42
Azospirillum	genus	1.42	0.64
Luteolibacter algae	species	0.78	1.41
Bilophila	genus	0.78	1.41
Actinobacillus pleuropneumoniae	species	1.39	0.69
Acetobacteraceae	family	1.38	0.72
Catenibacterium	genus	1.38	0.68
Caldilineae	class	1.37	0.76
Caldilineaceae	family	1.37	0.76
Caldilinea tarbellica	species	1.37	0.76
Caldilineales	order	1.37	0.76
Caldilinea	genus	1.37	0.76
Bilophila wadsworthia	species	0.79	1.36
Sutterella stercoricanis	species	1.35	0.76
Actinomycetota	phylum	1.34	0.80
Bifidobacterium dentium	species	1.33	0.80
Bacteroides salyersiae	species	1.33	0.80
Ruminococcus callidus	species	1.32	0.80
Schaalia	genus	1.32	0.78
Prevotella dentasini	species	1.31	0.80
Actinomycetes	class	1.31	0.81
Schaalia naturae	species	1.31	0.63
Brachybacterium	genus	1.31	0.41
Anaerolineae	class	1.30	0.79
Bifidobacteriaceae	family	1.30	0.81
Bifidobacteriales	order	1.30	0.81
Desulfovibrio simplex	species	1.30	0.81
Thermosediminibacterales	order	1.29	0.79
Bifidobacterium	genus	1.29	0.82
Oribacterium	genus	1.29	0.82
Turicibacteraceae	family	1.28	0.82
Turicibacter	genus	1.28	0.82
Tepidibacter	genus	1.28	0.75
Alishewanella	genus	1.28	0.55
Candidatus Tammella caduceiae	species	1.27	0.72
Candidatus Tammella	genus	1.27	0.72
Oribacterium sinus	species	1.27	0.82
Mannheimia	genus	1.27	0.82
Mesoplasma entomophilum	species	1.27	0.81
Coprococcus eutactus	species	1.26	0.83
Heliorestis	genus	1.25	0.82
Chloroflexota	phylum	1.25	0.77
Luteibacter anthropi	species	1.25	0.83
Streptococcus sanguinis	species	1.25	0.74
Neisseriales	order	1.25	0.78
Tepidanaerobacteraceae	family	1.25	0.82
Tepidanaerobacter syntrophicus	species	1.25	0.82
Tepidanaerobacter	genus	1.25	0.82
Mannheimia caviae	species	1.24	0.82
Luteibacter	genus	1.24	0.84
Holdemanella biformis	species	1.24	0.81
Holdemanella	genus	1.24	0.81
Entomoplasmataceae	family	1.24	0.83
Entomoplasmatales	order	1.24	0.83
Mesoplasma	genus	1.24	0.83
Anaeroplasma	genus	1.24	0.82
Anaeroplasmatales	order	1.24	0.82
Anaeroplasmataceae	family	1.24	0.82
Succinivibrionaceae	family	1.24	0.80
Natranaerobiales	order	1.24	0.84
Coraliomargarita akajimensis	species	1.24	0.62
Coraliomargaritaceae	family	1.24	0.62
Coraliomargarita	genus	1.24	0.62
Schaalia odontolytica	species	1.24	0.76
Chroococcus minutus	species	1.24	0.80
Chroococcus	genus	1.24	0.80
Chroococcaceae	family	1.24	0.80
Morganellaceae	family	1.24	0.74
Ligilactobacillus	genus	1.24	0.76
Sphingomonas	genus	1.23	0.58
Anaerobranca	genus	1.23	0.83
Anaerobranca zavarzinii	species	1.23	0.83
Proteinivoraceae	family	1.23	0.83
Helicobacteraceae	family	1.23	0.65
Dermabacteraceae	family	1.23	0.63
Syntrophomonadaceae	family	1.23	0.84
Helicobacter	genus	1.23	0.65
Lactococcus lactis	species	1.23	0.84
Slackia	genus	1.23	0.84
Sutterella sanguinus	species	1.23	0.84
Streptococcus infantis	species	1.22	0.79
Sporotomaculum	genus	1.22	0.81
Desulfallaceae	family	1.22	0.81
Streptococcus oralis	species	1.22	0.78
Bifidobacterium longum	species	1.22	0.85
Lactococcus	genus	1.22	0.84
Bifidobacterium asteroides	species	1.21	0.79
Succinivibrio	genus	1.21	0.83
Coprococcus	genus	1.21	0.85
Bifidobacterium adolescentis	species	1.21	0.84
Segatella albensis	species	1.21	0.83
Geobacillus	genus	1.21	0.77
Lachnobacterium	genus	1.21	0.85
Deferribacter	genus	1.21	0.37
Salisaeta	genus	1.21	0.66
Salisaetaceae	family	1.21	0.66
Atopobium fossor	species	1.20	0.72
Mollicutes	class	1.20	0.85
Mycoplasmatota	phylum	1.20	0.85
Devosia	genus	1.20	0.71
Devosiaceae	family	1.20	0.71
Salisaeta longa	species	1.20	0.66
Ectothiorhodospira	genus	1.20	0.62
Paraburkholderia phenoliruptrix	species	1.20	0.80
Deferribacter autotrophicus	species	1.20	0.38
Candidatus Phytoplasma	genus	1.20	0.84